ArticleScientific reports2023
Higher levels of Pseudomonas aeruginosa LasB elastase expression are associated with early-stage infection in cystic fibrosis patients.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 18 citations in OpenAlex.
- Antibiofilm activity of Limosilactobacillus fermentum SH2 and Lactococcus lactis extracts against strains of methicillin-resistant Staphylococcus aureus, Staphylococcus hominis SH7, and Pseudomonas aeruginosa.Molecular biology reports · 2026Article
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- Exploring the Role ofACS infectious diseases · 2026Article
- Comprehensive characterization of virulence factors in Pseudomonas aeruginosa clinical isolates from Bushehr, Iran: High proportion of exoU-positive isolates.BMC microbiology · 2026Article
- Multiple virulence attenuating strategies against Pseudomonas aeruginosa: Natural, synthetic, and synergistic approaches.World journal of microbiology & biotechnology · 2026Review
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- Unraveling the immunosuppressive role of Elastase B produced by cystic fibrosis isolates ofVirulence · 2025Article
- The virulence trait and genotype distribution amongst the Pseudomonas aeruginosa clinical strains.BMC microbiology · 2025Article
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- Thymol combined with SAEW for the eradication of matureFrontiers in microbiology · 2025Article
- Exploring the antimicrobial potential of chitosan nanoparticles: synthesis, characterization and impact onNanoscale advances · 2024Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Pseudomonas aeruginosa is a common pathogen in cystic fibrosis (CF) patients and a major contributor to progressive lung damage. P. aeruginosa elastase (LasB), a key virulence factor, has been identified as a potential target for anti-virulence therapy. Here, we sought to differentiate the P. aeruginosa isolates from early versus established stages of infection in CF patients and to determine if LasB was associated with either stage. The lasB gene was amplified from 255 P. aeruginosa clinical isolates from 70 CF patients from the Toulouse region (France). Nine LasB variants were identified and 69% of the isolates produced detectable levels of LasB activity. Hierarchical clustering using experimental and clinical data distinguished two classes of isolates, designated as 'Early' and 'Established' infection. Multivariate analysis revealed that the isolates from the Early infection class show higher LasB activity, fast growth, tobramycin susceptibility, non-mucoid, pigmented colonies and wild-type lasR genotype. These traits were associated with younger patients with polymicrobial infections and high pFEV
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