ArticleNature communications2023
Acetylcholine modulates the temporal dynamics of human theta oscillations during memory.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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Who cites it
36 citing papers in PubMed, 51 citations in OpenAlex.
- Population Pharmacokinetic and Exposure-Response Analysis of the Cognitive Effects of TAK-071 in Participants With Parkinson Disease and Cognitive Impairment.Clinical pharmacology in drug development · 2025Trial
- Jangwon-hwan Improves Memory Performance in Mice with Enhanced Cholinergic Signaling and Synaptic Plasticity.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Acetylcholine: a candidate substrate for hippocampal predictive learning?Nature reviews. Neuroscience · 2026Review
- Excitatory cholecystokinin neurons in the CA3 area regulate the navigation learning and neuroplasticity.eLife · 2026Article
- Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.Annual review of neuroscience · 2026Review
- Article
- It's not just the phase: Frequency-dependent tuning of neuronal firing.PLoS biology · 2026Article
- From brain waves to heartbeats: Exploring the combined role of electroencephalography and heart-rate variability in Alzheimer's disease diagnosis and management.Journal of Alzheimer's disease : JAD · 2026Review
- Episodic memory encoding fluctuates at a theta rhythm of 3-10 Hz.Nature human behaviour · 2026Article
- Home-cage pharmacology in marmosets: behavioral effects of scopolamine.Psychopharmacology · 2026Article
- Unconscious Fear Requires Attention to Distort Vision in Safe Context.Neuroscience bulletin · 2026Article
- Neuroprotective effects of isoflavone-enriched soybean leaves (Frontiers in aging neuroscience · 2026Article
- Oscillatory dynamics as the coordination layer of the organism: waves, Markov blankets, and the virtual space of cognition.Frontiers in neuroscience · 2026Article
- Silent yet impaired: Hidden memory processing deficits in asymptomatic individuals with moderate-to-severe white matter hyperintensities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- JAK4D, a first-in-class thyrotropin-releasing hormone analogue, reverses scopolamine-induced memory deficits.Brain communications · 2026Article
- Scopolamine induced learning deficit in marmosets.Research square · 2025Article
- Scopolamine induced learning deficit in marmosets.bioRxiv : the preprint server for biology · 2025Article
- Modulation of speed-dependent acetylcholine release in the hippocampus by spatial task engagement.Cell reports · 2025Article
- Lateralization of Hippocampal Dentate Spikes and Sharp-Wave Ripples in Urethane Anesthetized Rats Depends on Cholinergic Tone.Hippocampus · 2025Article
- Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
The cholinergic system is essential for memory. While degradation of cholinergic pathways characterizes memory-related disorders such as Alzheimer's disease, the neurophysiological mechanisms linking the cholinergic system to human memory remain unknown. Here, combining intracranial brain recordings with pharmacological manipulation, we describe the neurophysiological effects of a cholinergic blocker, scopolamine, on the human hippocampal formation during episodic memory. We found that the memory impairment caused by scopolamine was coupled to disruptions of both the amplitude and phase alignment of theta oscillations (2-10 Hz) during encoding. Across individuals, the severity of theta phase disruption correlated with the magnitude of memory impairment. Further, cholinergic blockade disrupted connectivity within the hippocampal formation. Our results indicate that cholinergic circuits support memory by coordinating the temporal dynamics of theta oscillations across the hippocampal formation. These findings expand our mechanistic understanding of the neurophysiology of human memory and offer insights into potential treatments for memory-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.