Evidence map›Paper›PMID 37648380›Full record

ArticleBMJ open2023

Longitudinal cohort study investigating neurodevelopmental and socioemotional outcomes in school-entry aged children after open heart surgery in Australia and New Zealand: the NITRIC follow-up study protocol.

Debbie Long, Vicki A Anderson, Louise Crossley, Nikita Tuli Sood, Karina R Charles, Anna D MacDonald, Samudragupta Bora, Carmela F Pestell, Kathryn Murrell, Natalie A Pride and 24 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. The Australian and New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG): 20 Years of Collaborative Research.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 11 institutions in 6 countries.

Debbie LongSchool of Nursing, Queensland University of Technology, Kelvin Grove, Queensland, Australia.ORCID 0000-0002-0984-9559
Vicki A AndersonClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID 0000-0001-5233-3147
Louise CrossleyClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Nikita Tuli SoodClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID 0000-0002-9590-1842
Karina R CharlesSchool of Nursing, Queensland University of Technology, Kelvin Grove, Queensland, Australia.ORCID 0000-0002-8279-5155
Anna D MacDonaldChild Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
Samudragupta BoraDepartment of Pediatrics, University Hospitals Rainbow Babies & Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.ORCID 0000-0003-2342-4482
Carmela F PestellSchool of Psychological Science, University of Western Australia, Crawley, Western Australia, Australia.ORCID 0000-0002-1737-7774
Kathryn MurrellConsult Liaison Team, Starship Children's Hospital, Auckland, New Zealand.
Natalie A PrideKids Neuroscience Centre, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Peter J AndersonTurner Institute for Brain and Mental Health, Monash University, Clayton, Victoria, Australia.ORCID 0000-0001-7430-868X
Nadia BadawiGrace Centre for Newborn Care, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.ORCID 0000-0001-6828-1636
Brian RoseChild Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
Heidi BailliePaediatric Intensive Care Unit, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Kate MastersonClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID 0000-0001-8323-1215
Jenipher Chumbes FloresPaediatric Intensive Care Unit, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Claire SherringPaediatric Intensive Care Unit, Starship Children's Hospital, Auckland, New Zealand.
Sainath RamanPaediatric Intensive Care Unit, Queensland Children's Hospital, South Brisbane, Queensland, Australia.ORCID 0000-0002-0152-9980
John BecaPaediatric Intensive Care Unit, Starship Children's Hospital, Auckland, New Zealand.
Simon EricksonPaediatric Intensive Care Unit, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Marino FestaPaediatric Intensive Care Unit, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Benjamin W AndersonQueensland Paediatric Cardiac Service, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
Prem VenugopalSchool of Medicine, The University of Queensland, South Brisbane, Queensland, Australia.ORCID 0000-0002-0416-7823
Deane YimDepartment of Paediatric Cardiology, Perth Children's Hospital, Nedlands, Western Australia, Australia.ORCID 0000-0003-0318-5330
David AndrewsDepartment of Cardiothoracic Surgery, Perth Children's Hospital, Nedlands, Western Australia, Australia.
Michael CheungClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Christian BrizardClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Thomas L GentlesPaediatrics, Child and Youth Health, The University of Auckland, Auckland, New Zealand.ORCID 0000-0001-6149-2596
Ajay IyengarPaediatric and Congenital Cardiac Service, Starship Children's Hospital, Auckland, New Zealand.ORCID 0000-0002-0609-674X
Ian NicholsonHeart Centre for Children, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
Julian AyerHeart Centre for Children, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.ORCID 0000-0003-4647-8061
Warwick ButtClinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia.ORCID 0000-0003-3543-1014
Luregn J SchlapbachChild Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.ORCID 0000-0003-2281-2598
Kristen S GibbonsChild Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia k.gibbons@uq.edu.au.ORCID 0000-0002-5679-0932
The University of Queensland · AUChildren's Hospital at Westmead · AURoyal Children's Hospital · AUPrincess Margaret Hospital for Children · AUIntensive Care Society · GBMurdoch Children's Research Institute · AUQueensland University of Technology · AUUniversity of Auckland · NZAustralian Regenerative Medicine Institute · AUStarship Children's Health · NZThe University of Western Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDespite growing awareness of neurodevelopmental impairments in children with congenital heart disease (CHD), there is a lack of large, longitudinal, population-based cohorts. Little is known about the contemporary neurodevelopmental profile and the emergence of specific impairments in children with CHD entering school. The performance of standardised screening tools to predict neurodevelopmental outcomes at school age in this high-risk population remains poorly understood. The NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) trial randomised 1371 children <2 years of age, investigating the effect of gaseous nitric oxide applied into the cardiopulmonary bypass oxygenator during heart surgery. The NITRIC follow-up study will follow this cohort annually until 5 years of age to assess outcomes related to cognition and socioemotional behaviour at school entry, identify risk factors for adverse outcomes and evaluate the performance of screening tools. METHODS AND ANALYSIS: Approximately 1150 children from the NITRIC trial across five sites in Australia and New Zealand will be eligible. Follow-up assessments will occur in two stages: (1) annual online screening of global neurodevelopment, socioemotional and executive functioning, health-related quality of life and parenting stress at ages 2-5 years; and (2) face-to-face assessment at age 5 years assessing intellectual ability, attention, memory and processing speed; fine motor skills; language and communication; and socioemotional outcomes. Cognitive and socioemotional outcomes and trajectories of neurodevelopment will be described and demographic, clinical, genetic and environmental predictors of these outcomes will be explored. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the Children's Health Queensland (HREC/20/QCHQ/70626) and New Zealand Health and Disability (21/NTA/83) Research Ethics Committees. The findings will inform the development of clinical decision tools and improve preventative and intervention strategies in children with CHD. Dissemination of the outcomes of the study is expected via publications in peer-reviewed journals, presentation at conferences, via social media, podcast presentations and medical education resources, and through CHD family partners. TRIAL REGISTRATION NUMBER: The trial was prospectively registered with the Australian New Zealand Clinical Trials Registry as 'Gene Expression to Predict Long-Term Neurodevelopmental Outcome in Infants from the NITric oxide during cardiopulmonary bypass to improve Recovery in Infants with Congenital heart defects (NITRIC) Study - A Multicentre Prospective Trial'.

trial registrationACTRN12621000904875.

Indexed as

Cardiac Surgical ProceduresNitric OxideAgedAustraliaChildChild, PreschoolCohort StudiesFollow-Up StudiesHumansInfantLongitudinal StudiesNew ZealandProspective StudiesQuality of LifeNitric OxideCongenital heart diseaseDevelopmental neurology & neurodisabilityPaediatric cardiac surgeryPaediatric cardiologyPaediatric intensive & critical care

Identifiers

PMID37648380
PMCPMC10471882
OpenAlexW4386295950

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.