Evidence map›Paper›PMID 37648112›Full record

Trial reportThe Journal of nutrition2023

Biofortified Yellow-Fleshed Potatoes Provide More Absorbable Zinc than a Commonly Consumed Variety: A Randomized Trial Using Stable Isotopes in Women in the Peruvian Highlands.

Reyna Liria-Domínguez, Mary Penny, Paul Antony Kroon, Gabriela Burgos, Jack Dainty, Christophe Zeder, Michael B Zimmermann, Janet King, Richard Mithen, Erick Boy and 2 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05154500 (Evaluating Iron and Zinc Bioavailability From Biofortified Potatoes to Reduce Malnutrition in the Andean Highlands), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05154500 nacompletednot on this map

Evaluating Iron and Zinc Bioavailability From Biofortified Potatoes to Reduce Malnutrition in the Andean Highlands

TypeinterventionalSponsorInstituto de Investigacion Nutricional, PeruRan2018 to 2022Enrolled179ConditionsBiofortification, PotatoArmsIron biofortified potato, Zinc biofortified potato
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 5 countries.

Reyna Liria-DomínguezInstituto de Investigación Nutricional, Lima, Peru.
Mary PennyInstituto de Investigación Nutricional, Lima, Peru.
Paul Antony KroonFood, Microbiome and Health Program, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Gabriela BurgosGenetics, Genomics, and Crop Improvement Division, International Potato Center, Lima, Peru.
Jack DaintyNorwich Medical School, University of East Anglia, Norwich, United Kingdom.
Christophe ZederETH Zürich, Laboratory of Human Nutrition, Department of Health Sciences and Technology, Institute of Food, Nutrition, and Health, Zurich, Switzerland.
Michael B ZimmermannETH Zürich, Laboratory of Human Nutrition, Department of Health Sciences and Technology, Institute of Food, Nutrition, and Health, Zurich, Switzerland.
Janet KingDepartment of Nutritional Sciences and Toxicology, University of California-Berkeley, Berkeley, CA, United States.
Richard MithenLiggins Institute, Waipapa Taumata Rau - The University of Auckland, Auckland, New Zealand.
Erick BoyHarvestPlus Programme, Innovation, Policy and Scaling Unit, International Food Policy Research Institute, Washington, DC, USA.
Olla Al-JaiballiFood, Microbiome and Health Program, Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Susan Fairweather-TaitNorwich Medical School, University of East Anglia, Norwich, United Kingdom. Electronic address: s.fairweather-tait@uea.ac.uk.
ETH Zurich · CHInstituto de Investigación Nutricional · PENorwich Research Park · GBUniversity of East Anglia · GBInternational Food Policy Research Institute · USInternational Potato Center · PEUniversity of Auckland · NZUniversity of California, Berkeley · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundZinc-biofortified potatoes have considerable potential to reduce zinc deficiency because of their low levels of phytate, an inhibitor of zinc absorption, and their high consumption, especially in the Andean region of Peru.

objectivesThe purpose of this study was to measure fractional and total zinc absorption from a test meal of biofortified compared with regular potatoes.

methodsWe undertook a single-blinded randomized crossover study (using

resultsThe zinc content of the biofortified potato and regular potato was 0.48 (standard deviation [SD]: 0.02) and 0.32 (SD: 0.03) mg/100 g fresh weight, respectively. Mean fractional zinc absorption (FZA) from the biofortified potatoes was lower than from the regular potatoes, 20.8% (SD: 5.4%) and 25.5% (SD: 7.0%), respectively (P < 0.01). However, total zinc absorbed was significantly higher (0.49; SD: 0.13 and 0.40; SD: 0.11 mg/500 g, P < 0.01, respectively).

conclusionsThe results of this study demonstrate that biofortified potatoes provide more absorbable zinc than regular potatoes. Zinc-biofortified potatoes could contribute toward reducing zinc deficiency in populations where potatoes are a staple food. This trial was registered at clinicaltrials.gov as NCT05154500.

Indexed as

MalnutritionSolanum tuberosumCross-Over StudiesFemaleFood, FortifiedHumansIsotopesPeruZincIsotopesZincbiofortified cropspotatoesstable isotopeszinc absorption

Identifiers

PMID37648112
PMCPMC10613720
OpenAlexW4386226952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.