ArticleEuropean heart journal2024
Stroke risk in women with atrial fibrillation.
Article in European heart journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Risk and protective factors for stroke and transient ischaemic attack in patients with atrial fibrillation: an umbrella review of meta-analyses.Heart (British Cardiac Society) · 2026Pooled it
- Atrial fibrillation and risk of myocardial infarction by sex and time since diagnosis. The Tromsø Study 1994-2021.European heart journal. Quality of care & clinical outcomes · 2026Article
- Article
- Age-Dependent Association between Heart Failure and Stroke Risk in Atrial Fibrillation: A Nationwide Cohort Study.Journal of the American Heart Association · 2026Article
- Interpretable machine learning models for stroke risk prediction in patients with newly diagnosed atrial fibrillation.NPJ digital medicine · 2026Article
- Female Sex-Related Stroke Risk in Atrial Fibrillation: A Thing From the Past?Circulation. Arrhythmia and electrophysiology · 2026Article
- Sex differences in stroke prognosis across reperfusion strategies: implications for prevention and quality of life.GeroScience · 2026Article
- Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Clinical implications of the recalibrated CHA₂DS₂-VA score for women after ischemic stroke: a prospective cohort study.Acta neurologica Belgica · 2025Observational
- [Epidemiology of atrial fibrillation/atrial flutter and its risk factors from 1990 to 2021: a systematic analysis and Mendelian randomization study based on the China and Global Burden of Disease Study 2021].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
- Global burden of atrial fibrillation/flutter attributable to a high body mass index (HBMI) from 1990-2021.BMC cardiovascular disorders · 2025Article
- Temporal trends in ischemic stroke and female sex as a risk modifier in atrial fibrillation: insights from non-anticoagulated Asian patients in a nationwide cohort study.The Lancet regional health. Western Pacific · 2025Article
- Explainable artificial intelligence for stroke risk stratification in atrial fibrillation.European heart journal. Digital health · 2025Review
- Article
- Global, regional, and national burden of atrial fibrillation and atrial flutter from 1990 to 2021: sex differences and global burden projections to 2046-a systematic analysis of the Global Burden of Disease Study 2021.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
- The Association of Malignancy With Stroke and Bleeding in Atrial Fibrillation: A Population-Based Cohort Study.JACC. CardioOncology · 2025Article
- Association between triglyceride glucose index and adverse cardiovascular prognosis in patients with atrial fibrillation without diabetes: a retrospective cohort study.Lipids in health and disease · 2025Article
- Temporal trends in mortality involving atrial fibrillation and rheumatic heart disease: a 25-year nationwide analysis.Frontiers in cardiovascular medicine · 2025Article
- Article
- Integrated Care Using the ABCGlobal heart · 2025Article
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
aimsFemale sex is associated with higher rates of stroke in atrial fibrillation (AF) after adjustment for other CHA2DS2-VASc factors. This study aimed to describe sex differences in age and cardiovascular care to examine their relationship with stroke hazard in AF.
methodsPopulation-based cohort study using administrative datasets of people aged ≥66 years diagnosed with AF in Ontario between 2007 and 2019. Cause-specific hazard regression was used to estimate the adjusted hazard ratio (HR) for stroke associated with female sex over a 2-year follow-up. Model 1 included CHA2DS2-VASc factors, with age modelled as 66-74 vs. ≥ 75 years. Model 2 treated age as a continuous variable and included an age-sex interaction term. Model 3 further accounted for multimorbidity and markers of cardiovascular care.
resultsThe cohort consisted of 354 254 individuals with AF (median age 78 years, 49.2% female). Females were more likely to be diagnosed in emergency departments and less likely to receive cardiologist assessments, statins, or LDL-C testing, with higher LDL-C levels among females than males. In Model 1, the adjusted HR for stroke associated with female sex was 1.27 (95% confidence interval 1.21-1.32). Model 2 revealed a significant age-sex interaction, such that female sex was only associated with increased stroke hazard at age >70 years. Adjusting for markers of cardiovascular care and multimorbidity further decreased the HR, so that female sex was not associated with increased stroke hazard at age ≤80 years.
conclusionOlder age and inequities in cardiovascular care may partly explain higher stroke rates in females with AF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.