Evidence map›Paper›PMID 37647423›Full record

ArticleImmunity, inflammation and disease2023

Receptors expressions on peripheral lymphocytes and CD4

Samuel Asamoah Sakyi, Tonnies Abeku Buckman, Kwame Yeboah-Mensah, Ebenezer Senu, Alfred Effah, Daniel Antwi-Berko, Dzifa Dey, Maxwell H Antwi, Joseph Yorke, Andy O Boateng and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Receptors expressions on peripheral lymphocytes and CD4Immunity, inflammation and disease · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Samuel Asamoah SakyiDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti Region, Ghana.
Tonnies Abeku BuckmanDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti Region, Ghana.
Kwame Yeboah-MensahDepartment of Medicine, School of Medicine and Dentistry, Komfo Anokye Teaching Hospital, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Ebenezer SenuDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti Region, Ghana.ORCID 0000-0002-2973-8952
Alfred EffahDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti Region, Ghana.
Daniel Antwi-BerkoNeurochemistry Laboratory, Department of Clinical Chemistry, VU University Medical Center (VUmc), Amsterdam, The Netherlands.
Dzifa DeyDepartment of Medicine and Therapeutics, Korle-Bu Teaching Hospital, University of Ghana Medical School, Accra, Ghana.
Maxwell H AntwiDepartment of Medical Laboratory Sciences, Koforidua Technical University, Koforidua, Ghana.
Joseph YorkeDepartment of Surgery, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Andy O BoatengDepartment of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti Region, Ghana.
Akwasi M AddeiDepartment of Biological Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti Region, Ghana.
Muniru M TankoDepartment of Immunology and Immunodiagnostics, University for Development Studies, Tamale, Northern Region, Ghana.
Richard BoatengDepartment of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ashanti Region, Ghana.
Kwame Nkrumah University of Science and Technology · GHKomfo Anokye Teaching Hospital · GHAmsterdam UMC Location Vrije Universiteit Amsterdam · NLKoforidua Technical University · GHUniversity for Development Studies · GHUniversity of Ghana · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundT cell receptors play important roles in the development and progression of rheumatoid arthritis (RA). Their involvement has been reported in inflammatory autoimmune diseases. However, their role in predicting RA is still under exploration. This study evaluated the expression of CD183 (CXCR3) receptors on T-cells and other relevant biomarkers for detecting RA and determine their relationship with disease activity.

methodsThis unmatched case-control study included 48 newly diagnosed RA patients and 30 apparent healthy controls from the orthopedic units of Komfo Anokye Teaching Hospital (KATH), Kumasi and Korle-Bu Teaching Hospital (KBTH), Accra, Ghana. Sociodemographic data was obtained, and blood samples were also collected and processed for flow cytometric analysis. Statistical analyses were done using SPSS version 26.0 and R programming language. p < .05 was considered statistically significant.

resultsThis study found a significant difference in age group (p < .0001), marital status (p = .0210), occupation (p = .0140), educational level (p = .0210) and religion (p = .0100) between RA patients and healthy controls. Moreover, hemoglobin level (p = .0010), waist circumference (p < .0001) and hip circumference (p = .0040) were significantly different between RA patients and controls. RA patients had significantly lower levels of CD4

conclusionCD4

Indexed as

Arthritis, RheumatoidAutoimmune DiseasesCase-Control StudiesCD4-Positive T-LymphocytesGhanaHumansCD4+CD183+chemokine receptorsdiagnostics biomarkerdisease activity scorereceptor expressionrheumatoid arthritis

Identifiers

PMID37647423
PMCPMC10465995
OpenAlexW4386275126

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.