Evidence map›Paper›PMID 37647391›Full record

ArticleScience advances2023

TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating ribosome biogenesis.

Pengcheng Yu, Ning Qu, Rui Zhu, Jiaqian Hu, Peizhen Han, Jiahao Wu, Licheng Tan, Hualei Gan, Cong He, Chuantao Fang and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 1 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
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  6. Article
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Article
  14. Article
  15. BRAF mutation and tumor immune microenvironment in new era.American journal of cancer research · 2026
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Sphingolipid Metabolism in the Pathogenesis of Hashimoto's Thyroiditis.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Pengcheng YuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID 0000-0001-5390-3308
Ning QuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID 0000-0001-5670-4451
Rui ZhuInstitute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China.ORCID 0000-0003-1442-8502
Jiaqian HuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID 0000-0002-0142-6498
Peizhen HanDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Jiahao WuDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID 0009-0003-7946-5520
Licheng TanDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Hualei GanDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Cong HeDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Chuantao FangInstitute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China.
Yubin LeiInstitute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China.ORCID 0000-0002-4468-8076
Jian LiInstitute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China.ORCID 0000-0001-6608-7960
Chenxi HeInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.ORCID 0000-0001-9421-6707
Fei LanInstitutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Xiao ShiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Wenjun WeiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Yu WangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Qinghai JiDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.
Fa-Xing YuInstitute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China.ORCID 0000-0003-4834-9335
Yu-Long WangDepartment of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai, China.ORCID 0000-0002-3830-7257
Shanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TERT reactivation occurs frequently in human malignancies, especially advanced cancers. However, in vivo functions of TERT reactivation in cancer progression and the underlying mechanism are not fully understood. In this study, we expressed TERT and/or active BRAF (

Indexed as

AdenocarcinomaTelomeraseThyroid NeoplasmsAnimalsCell DedifferentiationHumansMiceProto-Oncogene Proteins B-rafRibosomesRNA, RibosomalBRAF protein, humanProto-Oncogene Proteins B-rafRNA, RibosomalTelomeraseTERT protein, human

Identifiers

PMID37647391
PMCPMC10468137
OpenAlexW4386276960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.