Evidence map›Paper›PMID 37647262›Full record

ArticleGut microbes2023

Linking serum vitamin D levels with gut microbiota after 1-year lifestyle intervention with Mediterranean diet in patients with obesity and metabolic syndrome: a nested cross-sectional and prospective study.

Hatim Boughanem, Patricia Ruiz-Limón, Jesús Pilo, José Manuel Lisbona-Montañez, Francisco J Tinahones, Isabel Moreno Indias, Manuel Macías-González

Abstract read
In one paragraph

Article in Gut microbes, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. The bile acid-gut microbiota-vitamin D axis: new insights into biliary atresia.Frontiers in cellular and infection microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hatim BoughanemDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain.
Patricia Ruiz-LimónDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain.
Jesús PiloDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain.
José Manuel Lisbona-MontañezDepartment of Rheumatology, Regional University Hospital of Málaga, Malaga, Spain.
Francisco J TinahonesDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain.
Isabel Moreno IndiasDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain.
Manuel Macías-GonzálezDepartment of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain.ORCID 0000-0002-6475-4704

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D, microbiota, and the Mediterranean diet (MedDiet) have been the focus of recent research due to their potential role in maintaining overall health. We hypothesize that MedDiet may alter the gut microbiota profile through changes in vitamin D levels. We aimed to investigate changes in gut microbiota and serum vitamin D levels after a MedDiet within a lifestyle intervention. The study included 91 patients with obesity and metabolic syndrome, who were categorized based on their serum vitamin D levels as having either optimal or low 25-hydroxyvitamin D [25(OH)D levels]. The profile of the gut microbiota was analyzed by the 16S rRNA sequencing, inferring its functionality through PICRUsT. Participants underwent a hypocaloric MedDiet and change in their lifestyle for 1 year, and the profile and functionality of their gut microbiota were evaluated by analyzing inter-individual differences in time. At baseline, gut microbiota profiles qualitatively differed between participants with Optimal or Low 25(OH)D levels [Unweighted (

Indexed as

Diet, MediterraneanGastrointestinal MicrobiomeMetabolic SyndromeCross-Sectional StudiesHumansLife StyleObesityProspective StudiesRNA, Ribosomal, 16SVitamin DVitaminsRNA, Ribosomal, 16SVitamin DVitamins25-hydroxyvitamin Dgut microbiotaMedDietmediterranean dietmetabolic syndromeobesityvitamin D

Identifiers

PMID37647262
PMCPMC10469434

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.