Evidence map›Paper›PMID 37647215›Full record

ArticleeLife2023

A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells.

Sana Ahmed-Seghir, Manisha Jalan, Helen E Grimsley, Aman Sharma, Shyam Twayana, Settapong T Kosiyatrakul, Christopher Thompson, Carl L Schildkraut, Simon N Powell

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. DNA Damage and Replication Stress Checkpoints.Annual review of biochemistry · 2025
    Review
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sana Ahmed-Seghir *Department of Radiation Oncology and the Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.
Manisha Jalan *Department of Radiation Oncology and the Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0002-4467-4934
Helen E GrimsleyDepartment of Radiation Oncology and the Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0003-3485-0305
Aman SharmaDepartment of Radiation Oncology and the Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0003-1017-8307
Shyam TwayanaDepartment of Cell Biology, Albert Einstein College of Medicine, New York, United States.
Settapong T KosiyatrakulDepartment of Cell Biology, Albert Einstein College of Medicine, New York, United States.
Christopher ThompsonDepartment of Radiation Oncology and the Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.
Carl L SchildkrautDepartment of Cell Biology, Albert Einstein College of Medicine, New York, United States.
Simon N PowellDepartment of Radiation Oncology and the Molecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, United States.ORCID 0000-0002-8183-4765
Memorial Sloan Kettering Cancer Center · USAlbert Einstein College of Medicine · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI Ulrich Steidl · 1985 to 2026
$111.2M
Targeting Polθ to Overcome PARP Inhibitor Resistance in Homologous Recombination Deficient Breast CancerP50CA247749 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Sarat Chandarlapaty, Simon N. Powell · 2020 to 2026
$16.3M
DNA REPLICATION INITIATION SITES IN MAMMALIAN CELLSR01GM045751 · NIGMS · YESHIVA UNIVERSITY · PI SCHILDKRAUT, CARL L · 1992 to 2023
$13.4M
Training in Aging ResearchT32AG023475 · NIA · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI NIR J BARZILAI, DEREK Major HUFFMAN · 2004 to 2026
$8.6M
Role of Nucleases in RNA Primer Removal and MutagenesisR01CA085344 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI SHEN, BINGHUI · 1999 to 2024
$7.7M
The Response to a Site-Specific Blocked DNA Replication Fork in Human CancersR01CA187069 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI POWELL, SIMON N. · 2014 to 2018
$1.8M
NCI NIH HHS P30 CA008748NCI NIH HHS P30-CA008748NCI NIH HHS P30 CA013330NCI NIH HHS P30-CA013330NCI NIH HHS P50 CA247749NCI NIH HHS R01 CA085344NCI NIH HHS R01 CA187069NIA NIH HHS T32 AG023475NIGMS NIH HHS R01 GM045751NIH HHS P50-CA247749NIH HHS R01-CA085344NIH HHS R01-CA187069NIH HHS R01-GM045751NIH HHS T32AG023475
6 · The paper itself

Abstract

When replication forks encounter DNA lesions that cause polymerase stalling, a checkpoint pathway is activated. The ATR-dependent intra-S checkpoint pathway mediates detection and processing of sites of replication fork stalling to maintain genomic integrity. Several factors involved in the global checkpoint pathway have been identified, but the response to a single replication fork barrier (RFB) is poorly understood. We utilized the

Indexed as

DNA DamageDNA ReplicationAtaxia Telangiectasia Mutated ProteinsEscherichia coliGenomicsHumansPhosphorylationAtaxia Telangiectasia Mutated ProteinsATR protein, humanATRchromosomesDNA damageDNA replicationgene expressiongenomic instabilityhumanreplication stressTus-TerB

Identifiers

PMID37647215
PMCPMC10468204
OpenAlexW4377693487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.