Evidence map›Paper›PMID 37647207›Full record

ArticleReproduction (Cambridge, England)2023

Maternal restricted- and over- feeding during gestation perturb offspring sperm epigenome in sheep.

Linkai Zhu, Nicole Tillquist, Giovanna Scatolin, Rachael Gately, Mia Kawaida, Amanda Reiter, Sarah Reed, Steven Zinn, Kristen Govoni, Zongliang Jiang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproduction (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Pan-Omics in Sheep: Unveiling Genetic Landscapes.Animals : an open access journal from MDPI · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Linkai ZhuDepartment of Animal Sciences, Genetics Institute, University of Florida, Gainesville, Florida, USA.
Nicole TillquistDepartment of Animal Science, University of Connecticut, Storrs, Connecticut, USA.ORCID 0000-0001-8596-5335
Giovanna ScatolinDepartment of Animal Sciences, Genetics Institute, University of Florida, Gainesville, Florida, USA.
Rachael GatelyDepartment of Ambulatory Medicine and Theriogenology, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Massachusetts, USA.
Mia KawaidaDepartment of Animal Science, University of Connecticut, Storrs, Connecticut, USA.
Amanda ReiterDepartment of Animal Science, University of Connecticut, Storrs, Connecticut, USA.
Sarah ReedDepartment of Animal Science, University of Connecticut, Storrs, Connecticut, USA.
Steven ZinnDepartment of Animal Science, University of Connecticut, Storrs, Connecticut, USA.
Kristen GovoniDepartment of Animal Science, University of Connecticut, Storrs, Connecticut, USA.
Zongliang JiangDepartment of Animal Sciences, Genetics Institute, University of Florida, Gainesville, Florida, USA.ORCID 0000-0002-3040-7771
University of Connecticut · USUniversity of Florida · USTufts University · US

Funding

DNA Methylation at N6-Adenine in Placental Trophoblast DevelopmentR01HD102533 · NICHD · UNIVERSITY OF FLORIDA · PI JIANG, ZONGLIANG, XIAO, ZHUO ANDREW · 2020 to 2024
$3.1M
NICHD NIH HHS R01 HD102533
6 · The paper itself

Abstract

In brief: Inadequate maternal nutrition during gestation can have immediate and lifelong effects on offspring. This study shows that maternal restricted - and over- nutrition during gestation do not affect semen characteristics in F1 male offspring but alters offspring sperm sncRNA profiles and DNA methylome in sheep. Abstract: There is a growing body of evidence that inadequate maternal nutrition during gestation can have immediate and lifelong effects on offspring. However, little is known about the effects of maternal nutrition during gestation on male offspring reproduction. Here, using a sheep model of maternal restricted - and over - nutrition (60 or 140% of the National Research Council requirements) during gestation, we found that maternal restricted - and over - nutrition do not affect semen characteristics (i.e. volume, sperm concentration, pH, sperm motility, sperm morphology) or scrotal circumference in male F1 offspring. However, using small RNA sequencing analysis, we demonstrated that both restricted - and over - nutrition during gestation induced marked changes in composition and expression of sperm small noncoding RNAs (sncRNAs) subpopulations including in male F1 offspring. Whole-genome bisulfite sequencing analysis further identified specific genomic loci where poor maternal nutrition resulted in alterations in DNA methylation. These findings indicate that maternal restricted - and over - nutrition during gestation induce epigenetic modifications in sperm of F1 offspring sperm in sheep, which may contribute to environmentally influenced phenotypes in ruminants.

Indexed as

EpigenomeMalnutritionAnimalsFemaleMalePregnancyReproductionSemenSheepSpermatozoaSperm Motility

Identifiers

PMID37647207
PMCPMC10962644
OpenAlexW4386296036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.