ArticleAngewandte Chemie (International ed. in English)2023
Ultra-Small Air-Stable Triplet-Triplet Annihilation Upconversion Nanoparticles for Anti-Stokes Time-Resolved Imaging.
Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Interplay between Host Structure, Oxygen Quenching, and Triplet-Triplet Annihilation Upconversion in Hybrid Polymer Hosts.ACS applied optical materials · 2026Article
- Aminal-linked Covalent Organic Frameworks for Light Energy Upconversion.Angewandte Chemie (International ed. in English) · 2026Article
- PEG/Folic Acid Coloaded Er:YACS omega · 2026Article
- Methacrylate-based copolymers as tunable hosts for triplet-triplet annihilation upconversion.Materials advances · 2025Article
- Exploring the Versatile Uses of Triplet States: Working Principles, Limitations, and Recent Progress in Phosphorescence, TADF, and TTA.ACS applied optical materials · 2024Review
- Triplet-Triplet Annihilation Upconverting Liposomes: Mechanistic Insights into the Role of Membranes in Two-Dimensional TTA-UC.ACS applied materials & interfaces · 2024Article
- Supramolecular Annihilator with DPA Parallelly Arranged by Multiple Hydrogen-Bonding Interactions for Enhanced Triplet-Triplet Annihilation Upconversion.Molecules (Basel, Switzerland) · 2024Article
- Ambient solid-state triplet-triplet annihilation upconversion in ureasil organic-inorganic hybrid hosts.Journal of materials chemistry. C · 2024Article
- In Situ Glycan Analysis and Editing in Living Systems.JACS Au · 2024Review
- Ultra-Small Air-Stable Triplet-Triplet Annihilation Upconversion Nanoparticles for Anti-Stokes Time-Resolved Imaging.Angewandte Chemie (International ed. in English) · 2023Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
Abstract
Image contrast is often limited by background autofluorescence in steady-state bioimaging microscopy. Upconversion bioimaging can overcome this by shifting the emission lifetime and wavelength beyond the autofluorescence window. Here we demonstrate the first example of triplet-triplet annihilation upconversion (TTA-UC) based lifetime imaging microscopy. A new class of ultra-small nanoparticle (NP) probes based on TTA-UC chromophores encapsulated in an organic-inorganic host has been synthesised. The NPs exhibit bright UC emission (400-500 nm) in aerated aqueous media with a UC lifetime of ≈1 μs, excellent colloidal stability and little cytotoxicity. Proof-of-concept demonstration of TTA-UC lifetime imaging using these NPs shows that the long-lived anti-Stokes emission is easily discriminable from typical autofluorescence. Moreover, fluctuations in the UC lifetime can be used to map local oxygen diffusion across the subcellular structure. Our TTA-UC NPs are highly promising stains for lifetime imaging microscopy, affording excellent image contrast and potential for oxygen mapping that is ripe for further exploitation.
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