Evidence map›Paper›PMID 37647143›Full record

ArticleMolecular biology of the cell2023

Coordinated expression of replication-dependent histone genes from multiple loci promotes histone homeostasis in

Ashlesha Chaubal, Justin M Waldern, Colin Taylor, Alain Laederach, William F Marzluff, Robert J Duronio

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. The histone gene family inmicroPublication biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Cell-cycle-regulated transcriptional pausing ofMolecular biology of the cell · 2025
    Article
  7. Article
  8. Cell cycle-regulated transcriptional pausing ofbioRxiv : the preprint server for biology · 2024
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ashlesha ChaubalIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC 27599.
Justin M WaldernDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599.
Colin TaylorDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599.
Alain LaederachDepartment of Biology, University of North Carolina, Chapel Hill, NC 27599.
William F MarzluffIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC 27599.
Robert J DuronioIntegrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC 27599.
University of North Carolina at Chapel Hill · US

Funding

HISTONE MRNA REGULATION IN DEVELOPMENTR01GM058921 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DURONIO, ROBERT J, MARZLUFF, WILLIAM F. · 1999 to 2025
$11.6M
Non-coding RNA structure change in Chronic Obstructive Pulmonary DiseaseR01HL111527 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Alain T Laederach, Kevin M Weeks · 2012 to 2026
$6.6M
Epigenetic Control of the Cell Cycle During Animal DevelopmentR35GM145258 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Robert J Duronio · 2022 to 2026
$2.3M
Variant induced RNA structure change in human genetic diseaseR35GM140844 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAEDERACH, ALAIN T · 2021 to 2025
$2.1M
NHLBI NIH HHS R01 HL111527NIGMS NIH HHS R01 GM058921NIGMS NIH HHS R35 GM140844NIGMS NIH HHS R35 GM145258
6 · The paper itself

Abstract

Production of large amounts of histone proteins during S phase is critical for proper chromatin formation and genome integrity. This process is achieved in part by the presence of multiple copies of replication dependent (RD) histone genes that occur in one or more clusters in metazoan genomes. In addition, RD histone gene clusters are associated with a specialized nuclear body, the histone locus body (HLB), which facilitates efficient transcription and 3' end-processing of RD histone mRNA. How all five RD histone genes within these clusters are coordinately regulated such that neither too few nor too many histones are produced, a process referred to as histone homeostasis, is not fully understood. Here, we explored the mechanisms of coordinate regulation between multiple RD histone loci in

Indexed as

DrosophilaDrosophila ProteinsAnimalsDrosophila melanogasterHistonesHomeostasisRNA, MessengerDrosophila ProteinsHistonesRNA, Messenger

Identifiers

PMID37647143
PMCPMC10846616
OpenAlexW4386282868

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.