ArticleClinical oral investigations2023
Salivary pellicle modulates biofilm formation on titanium surfaces.
Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Salivary contamination during implant placement: effects on titanium surface properties and early osseointegration- a systematic review.BMC oral health · 2026Pooled it
- A DMAHDM-herbal hybrid gargle for orthodontic-associated complications via oral microbiota regulation, inflammation inhibition, and enamel protection.Materials today. Bio · 2026Article
- Dental implant nanotopography for peri-implant tissue stability: soft-tissue sealing, innate immune calibration, and active biointerface regulation.International journal of implant dentistry · 2026Review
- Modulating effect of salivary pellicle conditioning of titanium surfaces on the development of biofilms of Pseudomonas aeruginosa and Staphylococcus species.Scientific reports · 2026Article
- Surface-related factors affecting bacterial adhesion on dental implants: a short literature review.The journal of advanced prosthodontics · 2026Review
- Effect of Limosilactobacillus reuteri probiotic on dual-species biofilms of Streptococcus sobrinus and Candida albicans: an in vitro study.The Saudi dental journal · 2026Article
- An Innovative Oral Ex Vivo Biofilm Model for Antimicrobial Investigations.Pathogens (Basel, Switzerland) · 2026Article
- Non-Life (Basel, Switzerland) · 2026Article
- Salivary protein adsorption on titanium abutments: a comparative study of edentulous and partially edentulous patients.Frontiers in oral health · 2026Article
- Evaluation of surface roughness of titanium disks subjected to simulated oral conditions.BMC oral health · 2025Article
- Biomolecule-functionalized dental implant surfaces: Towards augmenting soft tissue integration.Bioactive materials · 2025Review
- Synergistic Effects of Polyphenols and Stannous Ions on Pellicle Modification and Erosion Protection In Situ.Dentistry journal · 2025Article
- From Salivary Dysfunction to Prosthetic Challenges in Xerostomia and Denture Retention with Oral Gels.Materials (Basel, Switzerland) · 2025Review
- Article
- Rhamnolipid 89 Biosurfactant Is Effective againstInternational journal of molecular sciences · 2023Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesThe present study aimed to evaluate the potential of the salivary pellicle (SP) formed on titanium (Ti) surfaces to modulate the formation of a biofilm composed of Streptococcus gordonii, Actinomyces naeslundii, Fusobacterium nucleatum, and Porphyromonas gingivalis. MATERIALS AND
methodsTi substrates were incubated for 2 h with a pool of saliva samples obtained from 10 systemically and periodontally healthy subjects. Enamel substrates were included as a biological reference. Scanning electron microscopy (SEM) and Raman spectroscopy analysis were used to analyze the formation of the salivary pellicle. After the SP formation, the surfaces were incubated for 12 h with a mix of Streptococcus gordonii, Actinomyces naeslundii, Fusobacterium nucleatum, and Porphyromonas gingivalis. The number of bacterial cells attached to each surface was determined by the XTT assay while bacterial viability was analyzed by fluorescence microscopy using the LIVE/DEAD® BacLight
resultsThe SEM and Raman spectroscopy analysis confirmed the presence of a salivary pellicle formed on the tested surfaces. Regarding the biofilm formation, the presence of the SP decreases the number of the bacterial cells detected in the test surfaces, compared with the uncover substrates. Even more, the SP-covered substrates showed similar bacterial counts in both Ti and enamel surfaces, meaning that the physicochemical differences of the substrates were less determinant than the presence of the SP. While on the SP-uncover substrates, differences in the bacterial adhesion patterns were directly related to the physicochemical nature of the substrates.
conclusionsThe salivary pellicle was the main modulator in the development of the biofilm consisting of representative oral bacteria on the Ti substrates. CLINICAL RELEVANCE: The results of this study provide valuable information on the modulatory effect of the salivary pellicle on biofilm formation; such information allows us to understand better the events involved in the formation of oral biofilms on Ti dental implants.
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