Evidence map›Paper›PMID 37646895›Full record

ReviewCurrent gastroenterology reports2023

Clostridioides difficile Infection in Pediatric Inflammatory Bowel Disease.

Seth A Reasoner, Maribeth R Nicholson

Open access · greenAbstract readReview
In one paragraph

Review in Current gastroenterology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Frontiers in pediatrics · 2025
    Review
  5. [Advances in the treatment ofZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Seth A ReasonerDivision of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-7791-1641
Maribeth R NicholsonImmunology & Inflammation (VI4), Vanderbilt Institute for Infection, Vanderbilt University Medical Center, Nashville, TN, USA. maribeth.r.nicholson@vumc.org.ORCID http://orcid.org/0000-0003-3941-5599
Monroe Carell Jr. Children's Hospital · USVanderbilt University Medical Center · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Immune, Microbial, and Metabolic Factors that Impact Clostridioides difficile and Inflammatory Bowel Disease in ChildrenK23AI156132 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NICHOLSON, MARIBETH RUTH · 2021 to 2025
$876k
NIAID NIH HHS K23 AI156132NIGMS NIH HHS T32 GM007347NIH HHS K23AI156132NIH HHS T32GM007347
6 · The paper itself

Abstract

purpose of reviewChildren with inflammatory bowel disease (IBD) are at increased risk of C. difficile infection (CDI) and experience worse outcomes associated with an infection. In this article, we review recent research on the incidence, diagnosis, complications, and treatment options for CDI in children with IBD. RECENT

findingsChildren with IBD have an elevated incidence of CDI, but their CDI risk does not associate with established risk factors in adults with IBD. Existing testing methodologies are inadequate at differentiating CDI from C. difficile colonization in children with IBD. Fecal microbiota transplantation offers a durable cure for recurrent CDI. CDI remains a frequent occurrence in children with IBD. Careful clinical monitoring should be used to diagnose CDI and patients with co-occurring IBD and CDI require careful surveillance for worse outcomes. Future research should explore the optimal diagnosis and treatment modalities in this unique patient population.

Indexed as

Clostridioides difficileClostridium InfectionsInflammatory Bowel DiseasesAdultChildFecal Microbiota TransplantationHumansRisk FactorsChildrenClostridioides difficileCrohn’s diseaseFecal microbiota transplantationUlcerative colitis

Identifiers

PMID37646895
PMCPMC10843265
OpenAlexW4386271501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.