Evidence map›Paper›PMID 37646865›Full record

ArticleEJNMMI radiopharmacy and chemistry2023

First-in-human study of a novel cell death tracer [

Taco Metelerkamp Cappenberg, Stijn De Schepper, Christel Vangestel, Stef De Lombaerde, Leonie Wyffels, Tim Van den Wyngaert, Jeffrey Mattis, Brian Gray, Koon Pak, Sigrid Stroobants and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05177640 (Early Prediction of Tumor Response to Treatment), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05177640 phase1completednot on this map

Early Prediction of Tumor Response to Treatment: Translation of 99mTc-Duramycin

TypeinterventionalSponsorUniversity Hospital, AntwerpRan2021 to 2021Enrolled6ConditionsHealthy VolunteersArms99mTc-Duramycin
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026
    Review
  2. Article
  3. Transplanted Murine Tumours SPECT Imaging withInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Taco Metelerkamp Cappenberg *Department of Nuclear Medicine, Antwerp University Hospital (UZA), Edegem, Belgium.
Stijn De Schepper *Department of Nuclear Medicine, Antwerp University Hospital (UZA), Edegem, Belgium.
Christel VangestelDepartment of Nuclear Medicine, Antwerp University Hospital (UZA), Edegem, Belgium.
Stef De LombaerdeDepartment of Nuclear Medicine, Antwerp University Hospital (UZA), Edegem, Belgium.
Leonie WyffelsDepartment of Nuclear Medicine, Antwerp University Hospital (UZA), Edegem, Belgium.
Tim Van den WyngaertDepartment of Nuclear Medicine, Antwerp University Hospital (UZA), Edegem, Belgium.
Jeffrey MattisMolecular Targeting Technologies, Inc., West Chester, PA, USA.
Brian GrayMolecular Targeting Technologies, Inc., West Chester, PA, USA.
Koon PakMolecular Targeting Technologies, Inc., West Chester, PA, USA.
Sigrid StroobantsDepartment of Nuclear Medicine, Antwerp University Hospital (UZA), Edegem, Belgium.
Filipe ElvasDepartment of Nuclear Medicine, Antwerp University Hospital (UZA), Edegem, Belgium. filipe.elvas@uantwerpen.be.ORCID http://orcid.org/0000-0001-9790-3369
University of Antwerp · BEMolecular Targeting Technologies (United States) · USAntwerp University Hospital · BE

Funding

Early Prediction of Tumor Response to Treatment: Clinical Translation of [99mTc]-DuramycinR01CA226531 · NCI · MOLECULAR TARGETING TECHNOLOGIES, INC. · PI PAK, KOON Y, STROOBANTS, SIGRID · 2019 to 2022
$2.2M
NCI NIH HHS R01 CA226531
6 · The paper itself

Abstract

backgroundImaging of cell death can provide an early indication of treatment response in cancer. [

resultsSix healthy volunteers (3 males, 3 females) were injected intravenously with [

conclusion[

trial registrationNCT05177640, Registered April 30, 2021, https://clinicaltrials.gov/study/NCT05177640 .

Indexed as

99mTc-duramycin SPECTApoptosisBiodistributionCell death imagingInternal dosimetry

Identifiers

PMID37646865
PMCPMC10468453
OpenAlexW4386271681

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.