Trial reportJournal of the American Heart Association2023
Changes in Left Ventricular Global Longitudinal Strain in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial.
Trial report in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Exenatide and glucagon co-infusion increases myocardial glucose uptake and improves markers of diastolic dysfunction in adults with type 2 diabetes.Scientific reports · 2025Trial
- Cardiac remodelling and clinical outcomes after mitral edge-to-edge repair with the PASCAL® system.European heart journal. Imaging methods and practice · 2026Article
- Impact of peak strain dispersion and septal flash on left ventricular myocardial work in patients with complete left bundle branch block.The international journal of cardiovascular imaging · 2026Article
- Assessment of left ventricular global longitudinal strain and echocardiographic changes before and after PCI in Vietnamese patients with stable angina - a single center study.BMC cardiovascular disorders · 2026Observational
- Echocardiographic Assessment of Patients Undergoing Mitral Valve Repair.Journal of cardiovascular development and disease · 2025Review
- [Short-term clinical efficacy of transcatheter edge-to-edge repair for moderate to severe mitral regurgitation].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025Article
- Primary mitral regurgitation, surgery in the transcatheter era: when the neighbourhood becomes noisy: a state-of-art review.European heart journal. Imaging methods and practice · 2025Review
- Contribution of 2 D strain in the detection of subtle myocardial involvement in group A and B patients with chronic obstructive pulmonary disease.Frontiers in medicine · 2025Article
- Prognostic Value of Speckle-tracking Echocardiography in Assessing Outcomes of Transcatheter Edge-to-edge Repair for Mitral Regurgitation.Journal of cardiovascular echographyReview
Corrections and comments
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Authors and funding
19 authors at 12 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Left ventricular (LV) global longitudinal strain (GLS) provides incremental prognostic information over LV ejection fraction in patients with heart failure (HF) and secondary mitral regurgitation. We examined the prognostic impact of LV GLS improvement in this population. Methods and Results The COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation) trial randomized symptomatic patients with HF with severe (3+/4+) mitral regurgitation to transcatheter edge-to-edge repair with the MitraClip device plus maximally tolerated guideline-directed medical therapy (GDMT) versus GDMT alone. LV GLS was measured at baseline and 6-month follow-up. The relationship between the improvement in LV GLS from baseline to 6 months and the composite of all-cause death or HF hospitalization between 6- and 24-month follow-up were assessed. Among 383 patients, 174 (45.4%) had improved LV GLS at 6-month follow-up (83/195 [42.6%] with transcatheter edge-to-edge repair+GDMT and 91/188 [48.4%] with GDMT alone;
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