Evidence map›Paper›PMID 37646176›Full record

ArticleCirculation. Arrhythmia and electrophysiology2023

Hypoxia Promotes Atrial Tachyarrhythmias via Opening of ATP-Sensitive Potassium Channels.

Mark J Specterman, Qadeer Aziz, Yiwen Li, Naomi A Anderson, Leona Ojake, Keat-Eng Ng, Alison M Thomas, Malcolm C Finlay, Richard J Schilling, Pier D Lambiase and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Mark J SpectermanWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.J.S., Q.A., Y.L., N.A.A., L.O., K.-E.N., A.M.T., M.C.F., R.J.S., A.T.).ORCID 0000-0001-8533-2140
Qadeer AzizWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.J.S., Q.A., Y.L., N.A.A., L.O., K.-E.N., A.M.T., M.C.F., R.J.S., A.T.).ORCID 0000-0002-7636-6813
Yiwen LiWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.J.S., Q.A., Y.L., N.A.A., L.O., K.-E.N., A.M.T., M.C.F., R.J.S., A.T.).ORCID 0000-0002-0761-3649
Naomi A AndersonWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.J.S., Q.A., Y.L., N.A.A., L.O., K.-E.N., A.M.T., M.C.F., R.J.S., A.T.).
Leona OjakeWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.J.S., Q.A., Y.L., N.A.A., L.O., K.-E.N., A.M.T., M.C.F., R.J.S., A.T.).
Keat-Eng NgWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.J.S., Q.A., Y.L., N.A.A., L.O., K.-E.N., A.M.T., M.C.F., R.J.S., A.T.).
Alison M ThomasWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.J.S., Q.A., Y.L., N.A.A., L.O., K.-E.N., A.M.T., M.C.F., R.J.S., A.T.).ORCID 0000-0002-4936-7722
Malcolm C FinlayWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.J.S., Q.A., Y.L., N.A.A., L.O., K.-E.N., A.M.T., M.C.F., R.J.S., A.T.).
Richard J SchillingWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.J.S., Q.A., Y.L., N.A.A., L.O., K.-E.N., A.M.T., M.C.F., R.J.S., A.T.).ORCID 0000-0002-0621-8241
Pier D LambiaseInstitute of Cardiovascular Science, University College London, United Kingdom (P.D.L.).ORCID 0000-0002-9055-9267
Andrew TinkerWilliam Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (M.J.S., Q.A., Y.L., N.A.A., L.O., K.-E.N., A.M.T., M.C.F., R.J.S., A.T.).ORCID 0000-0001-7703-4151
Queen Mary University of London · GBCardiovascular Institute of the South · US

Funding

Roles of Endothelial and Smooth Muscle KATP Channels in Myocardial Ischemic InjuryR01HL146514 · NHLBI · LSU HEALTH SCIENCES CENTER · PI COETZEE, WILLIAM A, LEFER, DAVID JOSEPH · 2020 to 2023
$3.0M
British Heart Foundation RG/15/15/31742Medical Research Council MR/L016230/1NHLBI NIH HHS R01 HL146514
6 · The paper itself

Abstract

backgroundHypoxia-ischemia predisposes to atrial arrhythmia. Atrial ATP-sensitive potassium channel (K

methodsWhole heart K

resultsExpression patterns were essentially identical for all K

conclusionsK

Indexed as

Atrial FibrillationKATP ChannelsAdenosine TriphosphateAnimalsHeart AtriaHumansHypoxiaMiceTachycardiaTolbutamideAdenosine TriphosphateKATP ChannelsTolbutamideatrial fibrillationcardiac arrhythmiahypoxiaischemiaKATP channels

Identifiers

PMID37646176
PMCPMC10510820
OpenAlexW4386271317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.