ArticleHypertension (Dallas, Tex. : 1979)2023
Association of Supine Hypertension Versus Standing Hypotension With Adverse Events Among Middle-Aged Adults.
Article in Hypertension (Dallas, Tex. : 1979), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- A Review of Clinical Trial and Meta-Analyses of BP Treatment Strategies for Patients with Orthostatic Hypotension: Blood Pressure Management in Patients with Hypertension and Orthostatic Hypotension.Current hypertension reports · 2026Pooled it
- Associations of Hypertension and Orthostatic Hypotension With Subclinical Cardiovascular Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- Orthostatic Blood Pressure, Cardiovascular Disease, and Hypotensive Events.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Association of supine versus seated hypertension with cardiovascular events in older adults.European geriatric medicine · 2026Article
- Recent advances and emerging perspectives in vascular and cardiovascular research: A 2025 update.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Supine hypertension: hemodynamic and neurohumoral mechanisms-reflections on the hypertension research update and perspectives 2025.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Prevalence and associated factors of hearing loss in Iranian older adults: a cross- sectional study of Amirkola Health and Ageing Project.BMC geriatrics · 2026Article
- Approach to Cardiovascular Autonomic Dysfunction in Patients with Synucleinopathies.Movement disorders clinical practice · 2025Review
- Supine hypertension and cardiovascular disease: controversies and advances.Future cardiology · 2025Review
- Sit-up test for assessing impaired blood pressure regulation in community-dwelling older adults: a cross-sectional study.BMC geriatrics · 2025Article
- A reset on our reclined position-a call to prioritize neurogenic supine hypertension in the synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Review
- Article
- Supine Blood Pressure and Risk of Cardiovascular Disease and Mortality.JAMA cardiology · 2025Article
- Impact of vascular biomarkers and supine hypertension on cardiovascular outcomes in hypertensive patients: first results from the Cardiovascular Prognostic COUPLING Study in Japan.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Observational
- Orthostatic and Standing Hypertension and Risk of Cardiovascular Disease.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Cardio-ankle index, ankle-brachial index and supine hypertension for the improved prediction of cardiovascular outcomes in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Recent updates in autonomic research: orthostatic hypotension in prodromal synucleinopathy; longitudinal morbidity and mortality in orthostatic hypotension with and without supine hypertension; a cardiac vagal sensory system underlying reflex syncope.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundManagement of orthostatic hypotension (OH) prioritizes prevention of standing hypotension, sometimes at the expense of supine hypertension. It is unclear whether supine hypertension is associated with adverse outcomes relative to standing hypotension.
objectivesTo compare the long-term clinical consequences of supine hypertension and standing hypotension among middle-aged adults with and without OH.
methodsThe ARIC study (Atherosclerosis Risk in Communities) measured supine and standing blood pressure (BP) in adults aged 45 to 64 years, without neurogenic OH, between 1987 and 1989. We defined OH as a positional drop in systolic BP ≥20 mm Hg or diastolic BP ≥10 mm Hg, supine hypertension as supine BP≥140/≥90 mm Hg, and standing hypotension as standing BP≤105/≤65 mm Hg. Participants were followed for >30 years. We used Cox regression models to examine associations with cardiovascular disease events, all-cause mortality, falls, and syncope.
resultsOf 12 489 participants (55% female, 26% Black, mean age 54 years, SD 6), 4.4% had OH. Among those without OH (N=11 943), 19% had supine hypertension and 21% had standing hypotension, while among those with OH (N=546), 58% had supine hypertension and 38% had standing hypotension. Associations with outcomes did not differ by OH status (
conclusionsSupine hypertension was associated with higher risk of adverse events than standing hypotension, regardless of OH status. This challenges conventional OH management, which prioritizes standing hypotension over supine hypertension.
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