Evidence map›Paper›PMID 37646019›Full record

ArticleiScience2023

Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq.

Hui Li, Hongyi Liu, Yifei Liu, Xuefei Wang, Shiya Yu, Hongwen Huang, Xiangru Shen, Qi Zhang, Ni Hong, Wenfei Jin

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hui LiSchool of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Hongyi LiuSchool of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Yifei LiuSchool of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Xuefei WangSchool of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Shiya YuSchool of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Hongwen HuangSchool of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Xiangru ShenSchool of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Qi ZhangSchool of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Ni HongSchool of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Wenfei JinSchool of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Southern University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T cell activation is a key event in adaptive immunity. However, the dynamics and influencing factors of T cell activation remain unclear. Here, we analyzed CD4 T cells that were stimulated with anti-CD3/CD28 under several conditions to explore the factors affecting T cell activation. We found a stimulated T subset (HSP

Indexed as

Components of the immune systemImmune responseSpecialized functions of cellsTranscriptomics

Identifiers

PMID37646019
PMCPMC10460988
OpenAlexW4385687174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.