Evidence map›Paper›PMID 37645979›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Pregnancy-Associated Bleeding and Genetics: Five Sequence Variants in the Myometrium and Progesterone Signaling Pathway are associated with postpartum hemorrhage.

David Westergaard, Valgerdur Steinthorsdottir, Lilja Stefansdottir, Palle Duun Rohde, Xiaoping Wu, Frank Geller, Jaakko Tyrmi, Aki S Havulinna, Pol Sole Navais, Christopher Flatley and 35 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

45 authors at 17 institutions in 8 countries.

David WestergaardDepartment of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Valgerdur SteinthorsdottirdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Lilja StefansdottirdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Palle Duun RohdeDepartment of Health Science and Technology, Aalborg University, Gistrup, Denmark.
Xiaoping WuDepartment of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Frank GellerDepartment of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Jaakko TyrmiCentre for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Aki S HavulinnaInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Pol Sole NavaisDepartment of Obstetrics and Gynaecology, Institute of Clinical Science, University of Gothenburg, Gothenburg, Sweden.
Christopher FlatleyDepartment of Obstetrics and Gynaecology, Institute of Clinical Science, University of Gothenburg, Gothenburg, Sweden.
Sisse Rye OstrowskiDepartment of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Ole Birger PedersenDepartment of Clinical immunology, Zealand University Hospital, Køge, Denmark.
Christian ErikstrupDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.
Erik SørensenDepartment of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Christina MikkelsenDepartment of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Mie Topholm BrunClinical Immunological Research Unit, Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.
Bitten Aagaard JensenDepartment of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark.
Thorsten BrodersenDepartment of Clinical immunology, Zealand University Hospital, Køge, Denmark.
Henrik UllumDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
FinnGen
Danish Blood Donor Study Genomic Consortium
Estonian Biobank Research Team
Nordic Collaboration for Womens and Reproductive Health
Per MagnusDepartment of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
Ole A AndreassenNORMENT Centre, University of Oslo, Oslo, Norway.
Pål R NjolstadMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
Astrid Marie KolteDepartment of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Lone KrebsDepartment of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Mette NyegaardDepartment of Health Science and Technology, Aalborg University, Gistrup, Denmark.
Thomas Folkmann HansenNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Bjarke FenstraDepartment of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Mark DalyInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Cecilia M LindgrenBig Data Institute Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Gudmar ThorleifssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Olafur A StefanssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Gardar SveinbjornssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Daniel F GudbjartssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Unnur ThorsteinsdottirdeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Karina BanasikDepartment of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
Bo JacobssonDepartment of Obstetrics and Gynaecology, Institute of Clinical Science, University of Gothenburg, Gothenburg, Sweden.
Triin LaiskEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Hannele LaivuoriInstitute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
Kari StefanssondeCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Søren BrunakNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Henriette Svarre NielsenDepartment of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
University of Copenhagen · DKReykjavík University · ISStatens Serum Institut · DKdeCODE Genetics (Iceland) · ISBroad Institute · USNorwegian Institute of Public Health · NOOslo University Hospital · NOUniversity of Gothenburg · SEUniversity of Helsinki · FIAalborg University · DKAalborg University Hospital · DKAarhus University · DKCopenhagen University Hospital · DKHaukeland University Hospital · NOTampere University · FIUniversity of Southern Denmark · DKZealand University Hospital Køge · DK

Funding

Integrating genomic studies of gestational duration and birth weight to understand maternal and fetal causes of adverse pregnancy outcomes and links with later diseasesR01HD101669 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI FREATHY, RACHEL, JACOBSSON, BO · 2021 to 2024
$2.1M
NICHD NIH HHS R01 HD101669
6 · The paper itself

Abstract

Bleeding in early pregnancy and postpartum hemorrhage (PPH) bear substantial risks, with the former closely associated with pregnancy loss and the latter being the foremost cause of maternal death, underscoring the severity of these complications in maternal-fetal health. Here, we investigated the genetic variation underlying aspects of pregnancy-associated bleeding and identified five loci associated with PPH through a meta-analysis of 21,512 cases and 259,500 controls. Functional annotation analysis indicated candidate genes,

Identifiers

PMID37645979
PMCPMC10462219
OpenAlexW4385875520

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.