Evidence map›Paper›PMID 37645967›Full record

ArticlebioRxiv : the preprint server for biology2023

Insights into RAG evolution from the identification of "missing link" family A

Eliza C Martin, Lorlane Le Targa, Louis Tsakou-Ngouafo, Tzu-Pei Fan, Che-Yi Lin, Jianxiong Xiao, Yi Hsien Su, Andrei-Jose Petrescu, Pierre Pontarotti, David G Schatz

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 4 countries.

Eliza C MartinDepartment of Immunobiology, Yale School of Medicine, 300 Cedar Street, Box 208011, New Haven, CT, 06520-8011, United States.
Lorlane Le TargaAix-Marseille Université, IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille France.
Louis Tsakou-NgouafoAix-Marseille Université, IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille France.
Tzu-Pei FanInstitute of Cellular and Organismic Biology, Academia Sinica, 128 Academia Rd., Sec. 2, Nankang, Taipei 11529, Taiwan.
Che-Yi LinInstitute of Cellular and Organismic Biology, Academia Sinica, 128 Academia Rd., Sec. 2, Nankang, Taipei 11529, Taiwan.
Jianxiong XiaoDepartment of Immunobiology, Yale School of Medicine, 300 Cedar Street, Box 208011, New Haven, CT, 06520-8011, United States.
Yi Hsien SuInstitute of Cellular and Organismic Biology, Academia Sinica, 128 Academia Rd., Sec. 2, Nankang, Taipei 11529, Taiwan.
Andrei-Jose PetrescuDepartment of Bioinformatics and Structural Biochemistry, Institute of Biochemistry of the Romanian Academy, Splaiul Independentei 296, 060031, Bucharest, Romania.
Pierre PontarottiAix-Marseille Université, IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille France.
David G SchatzDepartment of Immunobiology, Yale School of Medicine, 300 Cedar Street, Box 208011, New Haven, CT, 06520-8011, United States.
Institute of Cellular and Organismic Biology, Academia Sinica · TWYale University · USAix-Marseille Université · FRCentre National de la Recherche Scientifique · FRInstitute of Biochemistry · RO

Funding

Function and Evolutionary Origins of the RAG EndonucleaseR01AI137079 · NIAID · YALE UNIVERSITY · PI David G. Schatz · 2018 to 2026
$5.1M
NIAID NIH HHS R01 AI137079
6 · The paper itself

Abstract

A series of "molecular domestication" events are thought to have converted an invertebrate RAG-like (RAGL) transposase into the RAG1-RAG2 (RAG) recombinase, a critical enzyme for adaptive immunity in jawed vertebrates. The timing and order of these events is not well understood, in part because of a dearth of information regarding the invertebrate

Indexed as

DDE transposaseevolutionRecombination activating gene (RAG)transpositiontransposon molecular domesticationV(D)J recombination

Identifiers

PMID37645967
PMCPMC10462144
OpenAlexW4386029680

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.