Evidence map›Paper›PMID 37645941›Full record

ArticlebioRxiv : the preprint server for biology2023

CryptoCEN: A Co-Expression Network for

Matthew J O'Meara, Jackson R Rapala, Connie B Nichols, Christina Alexandre, R Blake Billmyre, Jacob L Steenwyk, J Andrew Alspaugh, Teresa R O'Meara

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Matthew J O'MearaDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-3128-5331
Jackson R RapalaDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-0501-4615
Connie B NicholsDepartments of Medicine and Molecular Genetics/Microbiology; and Cell Biology, Duke University School of Medicine, Durham, North Carolina, USA.
Christina AlexandreDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
R Blake BillmyreDepartments of Pharmaceutical and Biomedical Sciences/Infectious Disease, College of Pharmacy/College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.ORCID 0000-0003-4866-3711
Jacob L SteenwykHowards Hughes Medical Institute and the Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-8436-595X
J Andrew AlspaughDepartments of Medicine and Molecular Genetics/Microbiology; and Cell Biology, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0003-3009-627X
Teresa R O'MearaDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8901-0154
University of Michigan · USDuke University · USHoward Hughes Medical Institute · USUniversity of Georgia · US

Funding

PREDOCTORAL TRAINING IN GENETICST32GM007544 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1985 to 2022
$11.3M
Michigan Predoctoral Training in GeneticsT32GM149391 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN V. MORAN · 2024 to 2026
$2.2M
Discovery of gene function and dissection of network re-wiring in non-model fungiR35GM147894 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Teresa R. OMeara · 2022 to 2026
$2.0M
Coordinated responses to host-derived stresses in C. neoformansR01AI175711 · NIAID · DUKE UNIVERSITY · PI ANDREW ALSPAUGH · 2023 to 2026
$1.5M
NIAID NIH HHS R01 AI175711NIGMS NIH HHS R35 GM147894NIGMS NIH HHS T32 GM007544NIGMS NIH HHS T32 GM149391
6 · The paper itself

Abstract

Elucidating gene function is a major goal in biology, especially among non-model organisms. However, doing so is complicated by the fact that molecular conservation does not always mirror functional conservation, and that complex relationships among genes are responsible for encoding pathways and higher-order biological processes. Co-expression, a promising approach for predicting gene function, relies on the general principal that genes with similar expression patterns across multiple conditions will likely be involved in the same biological process. For

Indexed as

Co-expressionCryptococcus neoformansFungal PathogenGene Function PredictionRNAseq

Identifiers

PMID37645941
PMCPMC10462067
OpenAlexW4386001194

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.