ArticlebioRxiv : the preprint server for biology2024
An atypical basement membrane forms a midline barrier during left-right asymmetric gut development in the chicken embryo.
Cora Demler, John Coates Lawlor, Ronit Yelin, Dhana Llivichuzcha-Loja, Lihi Shaulov, David Kim, Megan Stewart, Frank Lee, Natalia A Shylo, Paul A Trainor and 2 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors at 3 institutions in 2 countries.
Cora DemlerDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0003-3021-626X John Coates LawlorDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0001-8029-7585 Ronit YelinDepartment of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.
Dhana Llivichuzcha-LojaDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Lihi ShaulovRappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.
David KimDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Megan StewartDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Frank LeeDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Natalia A ShyloStowers Institute for Medical Research, Kansas City, MO, USA.
Thomas SchultheissDepartment of Genetics and Developmental Biology, Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel.
Natasza A KurpiosDepartment of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.ORCID 0000-0002-1251-7395 Cornell University · USTechnion – Israel Institute of Technology · ILStowers Institute for Medical Research · US
Funding
Mechanisms underlying form and function of the contractile gut lymphaticsR01DK092776 · NIDDK · CORNELL UNIVERSITY · PI Natasza A Kurpios · 2012 to 2026
$5.6MGut-specific lymphatic patterns and progenitor heterogeneity during intestinal health and diseaseR01DK107634 · NIDDK · CORNELL UNIVERSITY · PI KURPIOS, NATASZA A · 2017 to 2021
$2.0MBroad wavelength range Zeiss 780 NLO/confocal system for the Cornell Imaging CoreS10OD018516 · OD · CORNELL UNIVERSITY · PI ZIPFEL, WARREN R · 2014 to 2014
$834kZeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500kEvolutionary mechanisms of gastrulation and left-right patterning in amniotes.K99HD114881 · NICHD · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI SHYLO, NATALIA · 2024 to 2025
$200kNCRR NIH HHS S10 RR025502NICHD NIH HHS K99 HD114881NIDDK NIH HHS R01 DK092776NIDDK NIH HHS R01 DK107634NIH HHS S10 OD018516NIMHD NIH HHS L60 MD003100
6 · The paper itselfAbstract
Correct intestinal morphogenesis depends on the early embryonic process of gut rotation, an evolutionarily conserved program in which a straight gut tube elongates and forms into its first loops. However, the gut tube requires guidance to loop in a reproducible manner. The dorsal mesentery (DM) connects the gut tube to the body and directs the lengthening gut into stereotypical loops via left-right (LR) asymmetric cellular and extracellular behavior. The LR asymmetry of the DM also governs blood and lymphatic vessel formation for the digestive tract, which is essential for prenatal organ development and postnatal vital functions including nutrient absorption. Although the genetic LR asymmetry of the DM has been extensively studied, a divider between the left and right DM has yet to be identified. Setting up LR asymmetry for the entire body requires a
Indexed as
basement membranedorsal mesenterygutlamininleft-right asymmetrymidline barrierorganogenesis
Identifiers
PMID37645918
PMCPMC10461973
OpenAlexW4385875410
What OpenQuestion holds
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