Evidence map›Paper›PMID 37645913›Full record

ArticlebioRxiv : the preprint server for biology2023

Combination Treatment to Improve Mucociliary Transport of

Kaitlyn R Rouillard, Christopher P Esther, William J Kissner, Lucas M Plott, Dean W Bowman, Matthew R Markovetz, David B Hill

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kaitlyn R RouillardMarsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC 27599.
Christopher P EstherMarsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC 27599.
William J KissnerMarsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC 27599.
Lucas M PlottMarsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC 27599.
Dean W BowmanMarsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC 27599.
Matthew R MarkovetzMarsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC 27599.
David B HillMarsico Lung Institute, UNC Chapel Hill, Chapel Hill, NC 27599.
University of North Carolina at Chapel Hill · US

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5M
Project 4: Biophysical and structural characterization of airway submucosal gland mucus in health and diseaseP01HL164320 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Richard Charles Boucher, Michael Rubinstein · 2022 to 2026
$13.9M
NHLBI NIH HHS P01 HL164320NIDDK NIH HHS P30 DK065988
6 · The paper itself

Abstract

People with muco-obstructive pulmonary diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) often have acute or chronic respiratory infections that are difficult to treat due in part to the accumulation of hyperconcentrated mucus within the airway. Mucus accumulation and obstruction promote chronic inflammation and infection and reduce therapeutic efficacy. Bacterial aggregates in the form of biofilms exhibit increased resistance to mechanical stressors from the immune response (e.g., phagocytosis) and chemical treatments including antibiotics. Herein, combination treatments designed to disrupt the mechanical properties of biofilms and potentiate antibiotic efficacy are investigated against mucus-grown

Identifiers

PMID37645913
PMCPMC10461968
OpenAlexW4385837687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.