Evidence map›Paper›PMID 37645905›Full record

ArticlebioRxiv : the preprint server for biology2023

TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling.

Luyang Xiong, Irina Zhevlakova, Xiaoxia Z West, Detao Gao, Rakhylia Murtazina, Anthony Horak, J Mark Brown, Iuliia Molokotina, Eugene A Podrez, Tatiana V Byzova

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Luyang XiongDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic; Cleveland, OH 44195, USA.
Irina ZhevlakovaDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic; Cleveland, OH 44195, USA.
Xiaoxia Z WestDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic; Cleveland, OH 44195, USA.
Detao GaoDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic; Cleveland, OH 44195, USA.
Rakhylia MurtazinaDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic; Cleveland, OH 44195, USA.
Anthony HorakDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic; Cleveland, OH 44195, USA.
J Mark BrownDepartment of Cardiovascular & Metabolic Sciences, Lerner Research Institute, Cleveland Clinic; Cleveland, OH 44195, USA.
Iuliia MolokotinaDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic; Cleveland, OH 44195, USA.
Eugene A PodrezDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic; Cleveland, OH 44195, USA.
Tatiana V ByzovaDepartment of Neurosciences, Lerner Research Institute, Cleveland Clinic; Cleveland, OH 44195, USA.
Cleveland Clinic Lerner College of Medicine · US

Funding

Role of TLR2 in angiogenesisR01HL145536 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BYZOVA, TATIANA V · 2019 to 2022
$2.6M
NHLBI NIH HHS R01 HL145536
6 · The paper itself

Abstract

The etiology of hair loss remains enigmatic, and current remedies remain inadequate. Transcriptome analysis of aging hair follicles uncovered changes in immune pathways, including Toll-like receptors (TLRs). Our findings demonstrate that the maintenance of hair follicle homeostasis and the regeneration capacity after damage depends on TLR2 in hair follicle stem cells (HFSCs). In healthy hair follicles, TLR2 is expressed in a cycle-dependent manner and governs HFSCs activation by countering inhibitory BMP signaling. Hair follicles in aging and obesity exhibit a decrease in both TLR2 and its endogenous ligand carboxyethylpyrrole (CEP), a metabolite of polyunsaturated fatty acids. Administration of CEP stimulates hair regeneration through a TLR2-dependent mechanism. These results establish a novel connection between TLR2-mediated innate immunity and HFSC activation, which is pivotal to hair follicle health and the prevention of hair loss and provide new avenues for therapeutic intervention.

Identifiers

PMID37645905
PMCPMC10462054
OpenAlexW4385953285

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.