Evidence map›Paper›PMID 37645902›Full record

ArticlebioRxiv : the preprint server for biology2023

Cell arrangement impacts metabolic activity and antibiotic tolerance in

Hannah Dayton, Julie Kiss, Mian Wei, Shradha Chauhan, Emily LaMarre, William Cole Cornell, Chase J Morgan, Anuradha Janakiraman, Wei Min, Raju Tomer and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Hannah DaytonDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Julie KissDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Mian WeiDepartment of Chemistry, Columbia University, New York, NY 10025.
Shradha ChauhanDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Emily LaMarreProgram in Biology, The Graduate Center, City University of New York, New York, NY 10016.
William Cole CornellDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Chase J MorganDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Anuradha JanakiramanProgram in Biology, The Graduate Center, City University of New York, New York, NY 10016.
Wei MinDepartment of Chemistry, Columbia University, New York, NY 10025.
Raju TomerDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Alexa Price-WhelanDepartment of Biological Sciences, Columbia University, New York, NY 10025.
Jasmine A NirodyDepartment of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois 60637.
Lars E P DietrichDepartment of Biological Sciences, Columbia University, New York, NY 10025.

Funding

ClearScopeR44MH116827 · NIMH · MICROBRIGHTFIELD, LLC · PI GLASER, JACOB R · 2018 to 2022
$4.5M
Integration of redox-balancing mechanisms in Pseudomonas aeruginosa biofilmsR01AI103369 · NIAID · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DIETRICH, LARS · 2013 to 2022
$4.1M
A comparative approach for decomposing the mammalian brain architectural complexityDP2MH119423 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI TOMER, RAJU · 2018 to 2018
$2.4M
High-resolution volumetric imaging of metabolic activity in tissues and its application to tumor metabolismR01EB029523 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MIN, WEI · 2020 to 2023
$1.6M
NIAID NIH HHS R01 AI103369NIBIB NIH HHS R01 EB029523NIMH NIH HHS DP2 MH119423NIMH NIH HHS R44 MH116827
6 · The paper itself

Abstract

Cells must access resources to survive, and the anatomy of multicellular structures influences this access. In diverse multicellular eukaryotes, resources are provided by internal conduits that allow substances to travel more readily through tissue than they would via diffusion. Microbes growing in multicellular structures, called biofilms, are also affected by differential access to resources and we hypothesized that this is influenced by the physical arrangement of the cells. In this study, we examined the microanatomy of biofilms formed by the pathogenic bacterium

Indexed as

biofilm physiologyBiological Sciences (major)metabolic heterogeneityMicrobiology (minor)motility

Identifiers

PMID37645902
PMCPMC10462148

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.