ArticlemedRxiv : the preprint server for health sciences2024
Rare damaging
Open access · greenAbstract readPreprint
In one paragraph
Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
65 authors at 20 institutions in 2 countries.
Marios K GeorgakisInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany.
Rainer MalikInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany.
Omar El BounkariInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany.
Natalie R HasbaniHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jiang LiDepartment of Molecular and Functional Genomics, Geisinger Health System, Danville, Pennsylvania, USA.ORCID 0000-0002-7006-1285
Jennifer E HuffmanVeterans Affairs Healthcare System, Boston, MA, USA.
Gabrielle ShaktDepartment of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Reinier W P TackProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Tamara N KimballProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Yaw AsareInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Noah L TsaoDepartment of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-5743-0795
Renae JudyDepartment of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD.ORCID 0000-0003-4920-4744
Huichun XuDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD.ORCID 0000-0001-8118-9607
May E MontasserDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD.
Ron DoThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3144-3627
Eimear E KennyThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
James G TerryDepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-6659-3441
John Jeffrey CarrDepartment of Radiology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-4398-8237
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
W T LongstrethDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Kendra A YoungDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora CO, USA.
Sharon M LutzDepartment of Population Medicine, PRecisiOn Medicine Translational Research (PROMoTeR) Center, Harvard Pilgrim Health Care and Harvard Medical School, Boston, MA, USA.
Michael H ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4907-1657
Jai BroomeDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Alyna T KhanDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Fei Fei WangDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Nancy Heard-CostaDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Sudha SeshadriBigg's Institute for Alzheimer's Disease and neurodegenerative disorders, University of Texas Health Science Center, San Antonio, TX, USA.
Ramachandran S VasanDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Barry I FreedmanSection on Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Lisa R YanekDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-7117-1075
Brian G KralDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lewis C BeckerDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Patricia A PeyserDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Lawrence F BielakDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Farah AmmousDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
April P CarsonDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Michael E HallDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS.
Laura M RaffieldDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA USA.
Wendy S PostJohns Hopkins Bloomberg School of Public Health, Johns Hopkins School of Medicine, Baltimore, MD USA.
Russel P TracyDepartments of Pathology & Laboratory Medicine, and Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT USA.
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.
Xiuqing GuoThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.
Michael C MahaneyDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville TX USA.
Joanne E CurranDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville TX USA.
John BlangeroDepartment of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville TX USA.ORCID 0000-0001-6250-5723
Shoa L ClarkeDepartment of Medicine (Division of Cardiovascular Medicine), Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-6592-1172
Jeffrey W HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle WA 98109 USA.
Yao HuDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle WA 98109 USA.
Themistocles L AssimesDepartment of Medicine (Division of Cardiovascular Medicine), Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2349-0009
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle WA 98109 USA.
Jürgen BernhagenInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany.ORCID 0000-0003-2996-2652
Christopher D AndersonProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Scott M DamrauerDepartment of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Ramin ZandDepartment of Neurology, Pennsylvania State University, Hershey, Pennsylvania, USA.
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA.
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, Germany.
University of Washington · USBroad Institute · USJohns Hopkins University · USPhiladelphia VA Medical Center · USFred Hutch Cancer Center · USLudwig-Maximilians-Universität München · DEThe University of Texas Health Science Center at Houston · USThe University of Texas Rio Grande Valley · USUCLA Medical Center · USUniversity of Maryland, Baltimore · USUniversity of Michigan · USWake Forest University · USBoston University · USIcahn School of Medicine at Mount Sinai · USUniversity of Mississippi Medical Center · USVanderbilt University Medical Center · USVA Palo Alto Health Care System · USBrigham and Women's Hospital · USGeisinger Health System · USGenomic Health (United States) · US
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MGenetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MNorth Carolina Translational and Clinical Science Institute (NC TraCS) KL2KL2TR002490 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERGER, MORRIS · 2018 to 2022
$11.0MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MWhole-genome sequencing analysis of coronary atherosclerosis and related traitsR01HL146860 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DE VRIES, PAUL STEFAN · 2020 to 2024
$3.9MThe Genetic Epidemiology of Heart, Lung, and Blood TraitsTraining Grant (GenHLB)T32HL129982 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christy Leigh Avery, KAREN L. MOHLKE · 2016 to 2026
$3.8MMetabolomics of Neurocognitive Risk for Dementia in DiabetesR01AG058921 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALLRED, NICHOLETTE D. · 2019 to 2023
$3.8MSequencing Annotation and Functional Analysis in Risk of Intracerebral HemorrhageR01NS103924 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, CHRISTOPHER DAVID · 2018 to 2022
$3.4MTraining Program in Recovery and Restoration of CNS health and functionT32NS100663 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LEIGH R HOCHBERG, JONATHAN ROSAND · 2017 to 2026
$2.5MEPIDEMIOLOGY OF CORONARY CALCIFICATION IN THE ELDERLYR01HL064587 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B · 1999 to 2005
$2.2MCSRD VA IK2 CX001780NCATS NIH HHS KL2 TR002490NCATS NIH HHS UL1 TR001878NHLBI NIH HHS N01 HC085085NHLBI NIH HHS R01 HL064587NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL146860NHLBI NIH HHS T32 HL129982NHLBI NIH HHS U01 HL089856NIA NIH HHS R01 AG058921NIMH NIH HHS R01 MH129337NINDS NIH HHS R01 NS103924NINDS NIH HHS T32 NS100663
Abstract
Background: Previous work has shown a role of CCL2, a key chemokine governing monocyte trafficking, in atherosclerosis. However, it remains unknown whether targeting CCR2, the cognate receptor of CCL2, provides protection against human atherosclerotic cardiovascular disease. Methods: Computationally predicted damaging or loss-of-function (REVEL>0.5) variants within Results: Carriers of 45 predicted damaging or loss-of-function Conclusions: Carriers of an experimentally confirmed damaging
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atherosclerosiscardiovascular diseaseCCR2geneticsinflammation
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.