Evidence map›Paper›PMID 37645844›Full record

ArticlebioRxiv : the preprint server for biology2024

IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programs.

Keita Saeki, Richard Pan, Eunju Lee, Daisuke Kurotaki, Keiko Ozato

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Keita SaekiDivision of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892.ORCID 0000-0002-0611-176X
Richard PanDivision of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892.
Eunju LeeDivision of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892.
Daisuke KurotakiInternational Research Center for Medical Sciences, Kumamoto University, 860-011 Kumamoto City, Japan.
Keiko OzatoDivision of Developmental Biology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892.
National Institutes of Health · USKumamoto University · JP

Funding

FUNCTIONAL MAPPING OF THE MOUSE T COMPLEXF32HD008015 · NICHD · JACKSON LABORATORY · PI YOU, YUN · 1996 to 1998
–
NICHD NIH HHS F32 HD008015
6 · The paper itself

Abstract

Microglia are innate immune cells in the brain. Transcription factor IRF8 is highly expressed in microglia. However, its role in postnatal microglia development is unknown. We demonstrate that IRF8 binds stepwise to enhancer regions of postnatal microglia along with Sall1 and PU.1, reaching a maximum after day 14. IRF8 binding correlated with a stepwise increase in chromatin accessibility, which preceded the initiation of microglia-specific transcriptome. Constitutive and postnatal

Indexed as

Alzheimer’s diseaseenhancerIRF8microglia maturation

Identifiers

PMID37645844
PMCPMC10461927
OpenAlexW4382073509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.