Evidence map›Paper›PMID 37645823›Full record

ArticlebioRxiv : the preprint server for biology2023

Non-invasive Imaging Techniques for Monitoring Cellular Response to Treatment in Stable Vitiligo.

Jessica Shiu, Griffin Lentsch, Christopher M Polleys, Pezhman Mobasher, Marissa Ericson, Irene Georgakoudi, Anand K Ganesan, Mihaela Balu

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jessica ShiuDepartment of Dermatology, University of California, Irvine, Irvine, CA, USA.
Griffin LentschBeckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, USA.
Christopher M PolleysDepartment of Biomedical Engineering, Tufts University, Medford, MA, USA.
Pezhman MobasherDepartment of Dermatology, University of California, Irvine, Irvine, CA, USA.
Marissa EricsonBiostatistics, Epidemiology and Research Design, University of California, Irvine, Irvine, CA, USA.
Irene GeorgakoudiDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Anand K GanesanDepartment of Dermatology, University of California, Irvine, Irvine, CA, USA.
Mihaela BaluBeckman Laser Institute and Medical Clinic, University of California, Irvine, Irvine, CA, USA.
University of California, Irvine · USTufts University · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Institutional Career Development CoreKL2TR001416 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI CAIOZZO, VINCENT JAMES, DEMETRIOU, MICHAEL · 2015 to 2023
$5.6M
UCI P30 Skin Center Systems Biology CoreP30AR075047 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LANDER, ARTHUR D · 2019 to 2025
$5.1M
Development of a fast scanning, extended field-of-view multiphoton microscope for clinical skin imagingR01EB026705 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mihaela Balu, Anand K Ganesan · 2018 to 2026
$4.2M
Identifying the Molecular Characteristics of Migrating Melanocytes in Vitiligo SkinR21AR073408 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI GANESAN, ANAND K · 2018 to 2019
$374k
NCATS NIH HHS KL2 TR001416NCATS NIH HHS UL1 TR001414NIAMS NIH HHS P30 AR075047NIAMS NIH HHS R21 AR073408NIBIB NIH HHS R01 EB026705
6 · The paper itself

Abstract

Punch grafting procedures, where small pieces of normal skin are transplanted into stable vitiligo patches, results in repigmentation in only half of patients treated, yet the factors that determine whether a patient responds to treatment or not are still unknown. Reflectance confocal microscopy (RCM) is adept at visualizing melanocyte migration and epidermal changes over large areas while multiphoton microscopy (MPM) can capture metabolic changes in keratinocytes. With the overall goal of identifying optical biomarkers for early treatment response, we followed 12 vitiligo lesions undergoing punch grafting. Dendritic melanocytes adjacent to the graft site were observed before clinical evidence of repigmentation in treatment responsive patients but not in treatment non-responsive patients, suggesting that the early visualization of melanocytes is indicative of a therapeutic response. Keratinocyte metabolic changes in vitiligo skin adjacent to the graft site also correlated with treatment response, indicating that a keratinocyte microenvironment that more closely resembles normal skin is more hospitable for migrating melanocytes. Taken together, these studies suggest that successful melanocyte transplantation requires both the introduction of new melanocytes and modulation of the local tissue microenvironment.

Identifiers

PMID37645823
PMCPMC10462045
OpenAlexW4385921281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.