Evidence map›Paper›PMID 37645814›Full record

ArticlebioRxiv : the preprint server for biology2024

Sex Differences in Dopamine Release in Nucleus Accumbens and Dorsal Striatum Determined by Chronic Fast Scan Cyclic Voltammetry: Effects of social housing and repeated stimulation.

Ivette L Gonzalez, Christopher A Turner, Paras R Patel, Noah B Leonardo, Brandon D Luma, Julianna M Richie, Dawen Cai, Cynthia A Chestek, Jill B Becker

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ivette L GonzalezDepartment of Psychology, University of Michigan.
Christopher A TurnerDepartment of Psychology, University of Michigan.
Paras R PatelDepartment of Biomedical Engineering, University of Michigan.
Noah B LeonardoDepartment of Psychology, University of Michigan.
Brandon D LumaMichigan Neuroscience Institute, University of Michigan.
Julianna M RichieDepartment of Biomedical Engineering, University of Michigan.
Dawen CaiDepartment of Cell & Developmental Biology, University of Michigan.ORCID 0000-0003-4471-2061
Cynthia A ChestekDepartment of Biomedical Engineering, University of Michigan.
Jill B BeckerDepartment of Psychology, University of Michigan.
University of Michigan · US

Funding

NIDA Training Program in Neuroscience-Administrative SupplementT32DA007281 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Shelly Beth Flagel · 1995 to 2026
$5.7M
Optimization and distribution of high density cellular scale carbon and silicon arraysUF1NS107659 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHESTEK, CYNTHIA ANNE · 2018 to 2018
$3.4M
Social support, oxytocin and motivation for methamphetamineR01DA046403 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BECKER, JILL B. · 2019 to 2023
$2.4M
Intraretinal stimulation for high acuity artificial visionR01EY035008 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI James D Weiland · 2024 to 2026
$1.7M
Neural Engineering Training Program (NETP)T32NS115724 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI James D Weiland · 2021 to 2026
$1.2M
The role of GPER-1 and addictionR01DA049795 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BECKER, JILL B. · 2020 to 2022
$974k
NEI NIH HHS R01 EY035008NIDA NIH HHS R01 DA046403NIDA NIH HHS R01 DA049795NIDA NIH HHS T32 DA007281NINDS NIH HHS T32 NS115724NINDS NIH HHS UF1 NS107659
6 · The paper itself

Abstract

We investigated sex differences in dopamine (DA) release in the nucleus accumbens (NAc) and dorsolateral striatum (DLS) using a chronic 16-channel carbon fiber electrode and fast-scan cyclic voltammetry (FSCV). Electrical stimulation (ES; 60Hz) induced DA release was recorded in the NAc of single or pair-housed male and female rats. When core (NAcC) and shell (NAcS) were recorded simultaneously, there was greater ES DA release in NAcC of pair-housed females compared with single females and males. Housing did not affect ES NAc DA release in males. In contrast, there was significantly more ES DA release from the DLS of female rats than male rats. This was true prior to and after treatment with methamphetamine. Furthermore, in castrated (CAST) males and ovariectomized (OVX) females, there were no sex differences in ES DA release from the DLS, demonstrating the hormone dependence of this sex difference. However, in the DLS of both intact and gonadectomized rats, DA reuptake was slower in females than in males. Finally, DA release following ES of the medial forebrain bundle at 60Hz was studied over four weeks. ES DA release increased over time for both CAST males and OVX females, demonstrating sensitization. Using this novel 16-channel chronic FSCV electrode, we found sex differences in the effects of social housing in the NAcS, sex differences in DA release from intact rats in DLS, sex differences in DA reuptake in DLS of intake and gonadectomized rats, and we report sensitization of ES-induced DA release in DLS

Identifiers

PMID37645814
PMCPMC10462081
OpenAlexW4385953539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.