Evidence map›Paper›PMID 37645754›Full record

ArticlebioRxiv : the preprint server for biology2023

ATG2A-mediated bridge-like lipid transport regulates lipid droplet accumulation.

Justin L Korfhage, Neng Wan, Helin Elhan, Lisa Kauffman, Mia Pineda, Devin M Fuller, Abdou Rachid Thiam, Karin M Reinisch, Thomas J Melia

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Justin L KorfhageDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0002-8735-982X
Neng WanDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Helin ElhanLaboratoire de Physique de l'École Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité, 75005 Paris, France.
Lisa KauffmanLaboratoire de Physique de l'École Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité, 75005 Paris, France.
Mia PinedaDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Devin M FullerDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Abdou Rachid ThiamLaboratoire de Physique de l'École Normale Supérieure, ENS, Université PSL, CNRS, Sorbonne Université, Université Paris Cité, 75005 Paris, France.
Karin M ReinischDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.
Thomas J MeliaDepartment of Cell Biology, Yale University School of Medicine, New Haven, CT 06510.ORCID 0000-0002-5798-4624

Funding

Molecular Basis for Membrane Lipid HomeostasisR35GM131715 · NIGMS · YALE UNIVERSITY · PI KARIN M REINISCH · 2019 to 2026
$6.5M
Lipid flux during autophagosome membrane biogenesisR01GM135290 · NIGMS · YALE UNIVERSITY · PI MELIA, THOMAS JAMES · 2020 to 2023
$1.3M
ATG2 transfers lipids from ER exit site membranes to directly expand the growing autophagosomeF31AG079606 · NIA · YALE UNIVERSITY · PI FULLER, DEVIN · 2022 to 2024
$143k
NIA NIH HHS F31 AG079606NIGMS NIH HHS R01 GM135290NIGMS NIH HHS R35 GM131715
6 · The paper itself

Abstract

ATG2 proteins facilitate bulk lipid transport between membranes. ATG2 is an essential autophagy protein, but ATG2 also localizes to lipid droplets (LDs), and genetic depletion of ATG2 increases LD numbers while impairing fatty acid transport from LDs to mitochondria. How ATG2 supports LD homeostasis and whether lipid transport regulates this homeostasis remains unknown. Here we demonstrate that ATG2 is preferentially recruited to phospholipid monolayers such as those surrounding LDs rather than to phospholipid bilayers.

Identifiers

PMID37645754
PMCPMC10461963

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.