Evidence map›Paper›PMID 37645750›Full record

ArticlebioRxiv : the preprint server for biology2024

Hypoxia-inducible-factors differentially contribute to clinical disease and viral replication during RSV infection.

Dorothea R Morris, Yue Qu, Aline Haas de Mello, Yava L Jones-Hall, Tianshuang Liu, Meredith Weglarz, Teodora Ivanciuc, Roberto P Garofalo, Antonella Casola

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Dorothea R MorrisDepartment of Microbiology & Immunology, The University of Texas Medical Branch, Galveston, TX, USA.
Yue QuDepartment of Pediatrics, The University of Texas Medical Branch, Galveston, TX, USA.
Aline Haas de MelloDepartment of Pediatrics, The University of Texas Medical Branch, Galveston, TX, USA.
Yava L Jones-HallSchool of Veterinary Medicine and Biomedical Science, Texas A&M University, College Station, TX, USA.
Tianshuang LiuDepartment of Pediatrics, The University of Texas Medical Branch, Galveston, TX, USA.
Meredith WeglarzDepartment of Microbiology & Immunology, The University of Texas Medical Branch, Galveston, TX, USA.
Teodora IvanciucDepartment of Pediatrics, The University of Texas Medical Branch, Galveston, TX, USA.
Roberto P GarofaloDepartment of Microbiology & Immunology, The University of Texas Medical Branch, Galveston, TX, USA.
Antonella CasolaDepartment of Microbiology & Immunology, The University of Texas Medical Branch, Galveston, TX, USA.
The University of Texas Medical Branch at Galveston · USTexas A&M University · US

Funding

Virus, Tissue Culture and ImmunoassayP01AI062885 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI BOLDOGH, ISTVAN STEVEN · 2005 to 2022
$23.9M
UTMB Clinical and Translational Science AwardTL1TR001440 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HOMMEL, JONATHAN DEAN · 2015 to 2024
$3.4M
Role of Hypoxia-Inducible Factors (HIFs) in Respiratory Syncytial Virus InfectionR21AI175955 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CASOLA, ANTONELLA · 2023 to 2024
$440k
NCATS NIH HHS TL1 TR001440NIAID NIH HHS P01 AI062885NIAID NIH HHS R21 AI175955
6 · The paper itself

Abstract

Hypoxia-inducible-factors (HIF) are transcription factors that regulate cellular adaptation to hypoxic conditions, enabling cells to survive in low-oxygen environments. Viruses have evolved to activate this pathway to promote successful viral infection, therefore modulation of HIFs could represent a novel antiviral strategy. In previous

Indexed as

HIF-1aHIF-2ahypoxia-inducible-factorsPT2385PX478respiratory syncytial virusRSV

Identifiers

PMID37645750
PMCPMC10461990
OpenAlexW4385932931

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.