Evidence map›Paper›PMID 37645740›Full record

ArticlebioRxiv : the preprint server for biology2023

Effects of combined exposure to ethanol and delta-9-tetrahydrocannabinol during adolescence on synaptic plasticity in the prefrontal cortex of Long Evans rats.

Linyuan Shi, Shuo Kang, Chan Young Choi, Brynn L Noonan, Lauren K Carrica, Nu-Chu Liang, Joshua M Gulley

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Linyuan ShiDepartment of Psychology, University of Illinois, Urbana-Champaign.
Shuo KangNeuroscience Program, University of Illinois, Urbana-Champaign.
Chan Young ChoiDepartment of Psychology, University of Illinois, Urbana-Champaign.
Brynn L NoonanDepartment of Psychology, University of Illinois, Urbana-Champaign.
Lauren K CarricaDepartment of Psychology, University of Illinois, Urbana-Champaign.
Nu-Chu LiangDepartment of Psychology, University of Illinois, Urbana-Champaign.
Joshua M GulleyDepartment of Psychology, University of Illinois, Urbana-Champaign.
University of Illinois Urbana-Champaign · US

Funding

Mechanisms of metabolic and cognitive dysregulation after combined alcohol and THC useR21DA045175 · NIDA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GULLEY, JOSHUA M, LIANG, NU-CHU · 2018 to 2019
$372k
NIDA NIH HHS R21 DA045175
6 · The paper itself

Abstract

Significant exposure to alcohol or cannabis during adolescence can induce lasting disruptions of neuronal signaling in brain regions that are later to mature, such as the medial prefrontal cortex (mPFC). Considerably less is known about the effects of alcohol and cannabis co-use, despite its common occurrence. Here, we used male and female Long-Evans rats to investigate the effects of early-life exposure to ethanol, delta-9-tetrahydrocannabinol (THC), or their combination on high frequency stimulation (HFS)-induced plasticity in the prelimbic region of the mPFC. Animals were injected daily from postnatal days 30 to 45 with vehicle or THC (escalating doses, 3-20 mg/kg) and allowed to drink vehicle (0.1% saccharin) or 10% ethanol immediately after each injection.

Indexed as

adolescencedelta-9-tetrahydrocannabinolethanolGABAglycogen synthase kinase 3-betaplasticitypolydrug useprelimbic cortex

Identifiers

PMID37645740
PMCPMC10462006
OpenAlexW4385799511

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.