Evidence map›Paper›PMID 37645736›Full record

ArticlebioRxiv : the preprint server for biology2023

Transcriptional Profiles of Non-neuronal and Immune Cells in Mouse Trigeminal Ganglia.

Jennifer Mecklenburg, Sergey A Shein, Anahit H Hovhannisyan, Yi Zou, Zhao Lai, Shivani Ruparel, Alexei V Tumanov, Armen N Akopian

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jennifer Mecklenburg
Sergey A Shein
Anahit H Hovhannisyan
Yi Zou
Zhao Lai
Shivani Ruparel
Alexei V Tumanov
Armen N Akopian

Funding

Comprehensive functional phenotyping of trigeminal neurons innervating temporomandibular joint (TMJ) tissues in male, female and aged mice, primates, and humans with and without TMJ disorders (TMJD)..UC2AR082195 · NIAMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ARMEN N AKOPIAN, LINDSEY J MACPHERSON · 2022 to 2026
$8.4M
LIGHT and Lymphotoxin targeting for the treatment of chronic orofacial pain conditionsR01DE029187 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AKOPIAN, ARMEN N, RUPAREL, SHIVANI B · 2019 to 2021
$3.8M
NIAMS NIH HHS UC2 AR082195NIDCR NIH HHS R01 DE029187
6 · The paper itself

Abstract

Non-neuronal cells constitute 90-95% of sensory ganglia. These cells play critical roles in modulation of nociceptive signal transmissions by sensory neurons. Accordingly, the aim of this review-study was to identify, profile and summarize TG non-neuronal cell types in naïve male mice using published and our own data generated by single-cell RNA sequencing (scRNA-seq), flow cytometry (FC) and immunohistochemistry (IHC). TG contains 5 types of non-neuronal cells: glial, fibroblasts, smooth muscle, endothelial and immune cells. There is agreement among publications for glial, fibroblasts, smooth muscle and endothelial cells. Based on gene profiles, glial cells were classified as Schwann cells and satellite glial cells (SGC).

Identifiers

PMID37645736
PMCPMC10462109

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.