Evidence map›Paper›PMID 37645727›Full record

ArticlebioRxiv : the preprint server for biology2023

Bioluminescence Assay of Lysine Deacylase Sirtuin Activity.

Alexandria N Van Scoyk, Orlando Antelope, Anca Franzini, Donald E Ayer, Randall T Peterson, Anthony D Pomicter, Shawn C Owen, Michael W Deininger

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alexandria N Van ScoykUniversity of Utah, Department of Oncological Sciences.
Orlando AntelopeUniversity of Utah, Department of Pharmacology and Toxicology.
Anca FranziniUniversity of Utah, Department of Oncological Sciences.
Donald E AyerUniversity of Utah, Department of Oncological Sciences.
Randall T PetersonUniversity of Utah, Department of Pharmacology and Toxicology.
Anthony D PomicterUniversity of Utah, Division of Hematology Biorepository.
Shawn C OwenUniversity of Utah, Department of Molecular Pharmaceutics.
Michael W DeiningerBlood Research Institute, Versiti.
University of Utah · USMedical College of Wisconsin · US

Funding

A Bioluminescent Assay for Direct Measurement of Sirtuin Activity in Cancer CellsR21CA256128 · NCI · VERSITI WISCONSIN, INC. · PI DEININGER, MICHAEL W. · 2021 to 2022
$606k
NCI NIH HHS R21 CA256128
6 · The paper itself

Abstract

Lysine acylation can direct protein function, localization, and interactions. Sirtuins deacylate lysine towards maintaining cellular homeostasis, and their aberrant expression contributes to the pathogenesis of multiple pathological conditions, including cancer. Measuring sirtuins' activity is essential to exploring their potential as therapeutic targets, but accurate quantification is challenging. We developed 'SIRT

Identifiers

PMID37645727
PMCPMC10461969
OpenAlexW4385802350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.