Evidence map›Paper›PMID 37645682›Full record

ArticleAsian journal of pharmaceutical sciences2023

EVs-mediated delivery of CB2 receptor agonist for Alzheimer's disease therapy.

Yanjing Zhu, Ruiqi Huang, Deheng Wang, Liqun Yu, Yuchen Liu, Runzhi Huang, Shuai Yin, Xiaolie He, Bairu Chen, Zhibo Liu and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asian journal of pharmaceutical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yanjing ZhuKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopaedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai 200065, China.
Ruiqi HuangKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopaedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai 200065, China.
Deheng WangSchool of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Liqun YuKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopaedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai 200065, China.
Yuchen LiuKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopaedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai 200065, China.
Runzhi HuangKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopaedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai 200065, China.
Shuai YinKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopaedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai 200065, China.
Xiaolie HeKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopaedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai 200065, China.
Bairu ChenKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopaedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai 200065, China.
Zhibo LiuKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopaedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai 200065, China.
Liming ChengKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopaedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai 200065, China.
Rongrong ZhuKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Department of Orthopaedics, Tongji Hospital, School of Life Science and Technology, Tongji University, Shanghai 200065, China.
Tongji University · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a typical neurodegenerative disease that leads to irreversible neuronal degeneration, and effective treatment remains elusive due to the unclear mechanism. We utilized biocompatible mesenchymal stem cell-derived extracellular vesicles as carriers loaded with the CB2 target medicine AM1241 (EVs-AM1241) to protect against neurodegenerative progression and neuronal function in AD model mice. According to the results, EVs-AM1241 were successfully constructed and exhibited better bioavailability and therapeutic effects than bare AM1241. The Morris water maze (MWM) and fear conditioning tests revealed that the learning and memory of EVs-AM1241-treated model mice were significantly improved.

Indexed as

Alzheimer's diseaseCB2 receptor agonistExtracellular vesiclesNeurodegenerative disordersNeuronal regeneration

Identifiers

PMID37645682
PMCPMC10460952
OpenAlexW4385580208

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.