Evidence map›Paper›PMID 37645658›Full record

ArticleCurrent research in immunology2023

High baseline frequencies of natural killer cells are associated with asymptomatic SARS-CoV-2 infection.

Elizabeth K Graydon, Allison M W Malloy, Kawthar Machmach, Peifang Sun, Dominic Paquin-Proulx, Stephen Lizewski, Rhonda Lizewski, Dawn L Weir, Carl W Goforth, Stephen K Anderson and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Peripheral Immune Remodeling After Spinal Cord Injury: Marked by Expansion of CD38Neurology(R) neuroimmunology & neuroinflammation · 2026
    Observational
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elizabeth K GraydonDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Allison M W MalloyDepartment of Pediatrics, Uniformed Services University, Bethesda, MD, USA.
Kawthar MachmachHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Peifang SunInfectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD, USA.
Dominic Paquin-ProulxHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Stephen LizewskiNavy Medical Research Center, Silver Spring, MD, USA.
Rhonda LizewskiBureau of Medicine and Surgery, Arlington, VA, USA.
Dawn L WeirInfectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD, USA.
Carl W GoforthInfectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD, USA.
Stephen K AndersonBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Andrew G LetiziaInfectious Disease Directorate, Naval Medical Research Center, Silver Spring, MD, USA.
Edward MitreDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study tested the hypothesis that high frequencies of natural killer (NK) cells are protective against symptomatic SARS-CoV-2 infection. Samples were utilized from the COVID-19 Health Action Response for Marines study, a prospective, observational study of SARS-CoV-2 infection in which participants were enrolled prior to infection and then serially monitored for development of symptomatic or asymptomatic infection. Frequencies and phenotypes of NK cells (CD3

Indexed as

AsymptomaticNatural killer cellsNK cellsSARS-CoV-2Symptomatic

Identifiers

PMID37645658
PMCPMC10461189

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.