Evidence map›Paper›PMID 37645455›Full record

ArticleSleep advances : a journal of the Sleep Research Society2023

Reducing cognitive arousal and sleep effort alleviates insomnia and depression in pregnant women with DSM-5 insomnia disorder treated with a mindfulness sleep program.

David A Kalmbach, Philip Cheng, Anthony N Reffi, Jason C Ong, Leslie M Swanson, Colin A Espie, Grace M Seymour, Mika Hirata, Olivia Walch, D'Angela S Pitts and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Sleep advances : a journal of the Sleep Research Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04443959 (Telemedicine Mindfulness-based Therapy for Perinatal Insomnia), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04443959 nacompletednot on this map

Telemedicine Mindfulness-based Therapy for Perinatal Insomnia: An Open-label Trial.

TypeinterventionalSponsorHenry Ford Health SystemRan2022 to 2022Enrolled12ConditionsInsomniaArmsPUMAS
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

David A KalmbachThomas Roth Sleep Disorders & Research Center, Henry Ford Health, Detroit, MI, USA.
Philip ChengThomas Roth Sleep Disorders & Research Center, Henry Ford Health, Detroit, MI, USA.ORCID https://orcid.org/0000-0002-2874-658X
Anthony N ReffiThomas Roth Sleep Disorders & Research Center, Henry Ford Health, Detroit, MI, USA.ORCID https://orcid.org/0000-0002-2783-1678
Jason C OngCenter for Circadian and Sleep Medicine, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Leslie M SwansonDepartment of Psychiatry, University of Michigan, Ann Arbor, MI, USA.ORCID https://orcid.org/0000-0002-1720-1760
Colin A EspieNuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.
Grace M SeymourThomas Roth Sleep Disorders & Research Center, Henry Ford Health, Detroit, MI, USA.ORCID https://orcid.org/0000-0002-8696-8957
Mika HirataThomas Roth Sleep Disorders & Research Center, Henry Ford Health, Detroit, MI, USA.
Olivia WalchDepartment of Neurology, University of Michigan, Ann Arbor, MI, USA.
D'Angela S PittsDepartment of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University College of Human Medicine, East Lansing, MI, USA.
Thomas RothThomas Roth Sleep Disorders & Research Center, Henry Ford Health, Detroit, MI, USA.
Christopher L DrakeThomas Roth Sleep Disorders & Research Center, Henry Ford Health, Detroit, MI, USA.ORCID https://orcid.org/0000-0002-5486-3587
Henry Ford Health System · USUniversity of Michigan · USNorthwestern University · USNuffield Orthopaedic Centre · GB

Funding

A Wearable Morning Light Treatment for Postpartum Depression: Confirming Efficacy and MechanismsR01MH121531 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SWANSON, LESLIE M · 2021 to 2024
$2.3M
Identifying sleep-related risk factors for PTSD and their underlying mechanismsK23MH134032 · NIMH · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI Anthony Reffi · 2024 to 2026
$435k
NIMH NIH HHS K23 MH134032NIMH NIH HHS R01 MH121531
6 · The paper itself

Abstract

Objectives: Combining mindfulness with behavioral sleep strategies has been found to alleviate symptoms of insomnia and depression during pregnancy, but mechanisms for this treatment approach remain unclear. The present study examined nocturnal cognitive arousal and sleep effort as potential treatment mechanisms for alleviating insomnia and depression via a mindfulness sleep program for pregnant women. Methods: Secondary analysis from a proof-of-concept trial of 12 pregnant women with DSM-5 insomnia disorder who were treated with Perinatal Understanding of Mindful Awareness for Sleep (PUMAS), which places behavioral sleep strategies within a mindfulness framework. Data were collected across eight weekly assessments: pretreatment, six sessions, and posttreatment. Measures included the insomnia severity index (ISI), Edinburgh postnatal depression scale (EPDS), pre-sleep arousal scale's cognitive factor (PSASC), and the Glasgow sleep effort scale (GSES). We used linear mixed modeling to test cognitive arousal and sleep effort as concurrent and prospective predictors of insomnia and depression. Results: Most patients reported high cognitive arousal before PUMAS (75.0%), which decreased to 8.3% after treatment. All insomnia remitters reported low cognitive arousal after treatment, whereas half of nonremitters continued reporting high cognitive arousal. Both nocturnal cognitive arousal and sleep effort were associated with same-week changes in insomnia throughout treatment, and sleep effort yielded a prospective effect on insomnia. Lower levels of nocturnal cognitive arousal and sleep effort prospectively predicted reductions in depression. Conclusions: The present study offers preliminary evidence that reducing sleep effort and nocturnal cognitive arousal may serve as key mechanisms for alleviating insomnia and depression via mindfulness-based insomnia therapy. ClinicalTrials.gov ID: NCT04443959.

Indexed as

MBIMBSRmechanismmeditationpregnancyPUMASruminationstressworry

Identifiers

PMID37645455
PMCPMC10462399
OpenAlexW4385604277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.