Evidence map›Paper›PMID 37645380›Full record

ArticleFrontiers in cellular and infection microbiology2023

Macrophage susceptibility to infection by Ghanaian

Stephen Osei-Wusu, John K A Tetteh, Abdul Basit Musah, Desmond Opoku Ntiamoah, Nelly Arthur, Abraham Adjei, Ainhoa Arbues, Ebenezer Addo Ofori, Kwadwo Akyea Mensah, Sutaya Elsie Afua Galevo and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Stephen Osei-WusuNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
John K A TettehNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Abdul Basit MusahNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Desmond Opoku NtiamoahNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Nelly ArthurDepartment of Chest Diseases, Korle-Bu Teaching Hospital, Accra, Ghana.
Abraham AdjeiDepartment of Chest Diseases, Korle-Bu Teaching Hospital, Accra, Ghana.
Ainhoa ArbuesSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Ebenezer Addo OforiNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Kwadwo Akyea MensahNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Sutaya Elsie Afua GalevoNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Abena Frema FrempongNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Prince AsareNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Adwoa Asante-PokuNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Isaac Darko OtchereNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Kwadwo Asamoah KusiNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
Tobias L LenzResearch Group for Evolutionary Immunogenomics, Department of Biology, University of Hamburg, Hamburg, Germany.
Sebastien GagneuxSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Damien PortevinSwiss Tropical and Public Health Institute, Allschwil, Switzerland.
Dorothy Yeboah-ManuNoguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana.
University of Ghana · GHNoguchi Memorial Institute for Medical Research · GHKorle Bu Teaching Hospital · GHSwiss Tropical and Public Health Institute · CHUniversität Hamburg · DEUniversity of Basel · CH

Funding

Medical Research Council MR/P028071/1
6 · The paper itself

Abstract

Background: The epidemiology of Methods: The study participants consisted of 16 controls, among which self-reported Akan and Ewe ethnicity was equally represented, as well as 20 cured TB cases consisting of 11 Akans and 9 Ewes. Peripheral blood mononuclear cells were isolated from both healthy controls and cured TB cases. CD14 Results: We observed a higher capacity of MDMs from Ewes to phagocytose L4 strains (p < 0.001), translating into a higher bacillary load on day 7 (p < 0.001) compared to L5, despite the higher replication rate of L5 in Ewe MDMs (fold change: 1.4 Conclusion: Our results suggest that host ethnicity (driven by host genetic diversity), MTBC genetic diversity, and individual TB infection history are all acting together to modulate the outcome of macrophage infections by MTBC.

Indexed as

Latent TuberculosisMycobacterium tuberculosisAnimalsEthnicityFemaleGhanaHumansLeukocytes, MononuclearMacrophagesMethyl MethanesulfonateSelf ReportSheepmethylene dimethanesulfonateMethyl MethanesulfonateAkanethnicityEweGhanamacrophage infectionMycobacterium tuberculosis complextuberculosisWest Africa

Identifiers

PMID37645380
PMCPMC10461633
OpenAlexW4385836401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.