Evidence map›Paper›PMID 37645257›Full record

ArticlePhotoacoustics2023

Non-invasive evaluation of transdermal drug delivery using 3-D transient triplet differential (TTD) photoacoustic imaging.

Yang Xie, Huayi Wu, Ziyan Chen, Qi Sun, Xiangdong Liu, Jinsheng Jiang, Bo Wang, Zeyu Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photoacoustics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yang XieSchool of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Huayi WuSchool of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Ziyan ChenSchool of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Qi SunSchool of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Xiangdong LiuSchool of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Jinsheng JiangDepartment of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, China.
Bo WangDepartment of Biomedical Engineering, School of Basic Medical Science, Central South University, Changsha 410083, China.
Zeyu ChenSchool of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transdermal drug delivery (TDD) is less invasive and avoids first-pass metabolism, making it an attractive method for treating various diseases such as diabetes and hypertension. However, current methods for evaluating TDD systems lack in vivo descriptions of drug distribution in the skin. In this study, we demonstrate the capability of the Transient Triplet Differential (TTD) method, a non-invasive and background-free photoacoustic imaging technique, for accurately mapping drug distribution and evaluating different TDD systems. Our findings show that the TTD method can provide high sensitivity and specificity for targeted drug extraction and visualize 3D drug distribution in the skin. Furthermore, in vivo experiments confirmed the potential of the TTD method in evaluating the clinical performance of TDD. It's predictable that the TTD method can be a reliable and non-invasive approach for evaluating TDD systems and offer valuable insights into TDD research and development.

Indexed as

3D imagingBackground-freeEvaluation of transdermal drug deliveryNon-invasivePhotoacoustic imagingTransient triplet differential (TTD) method

Identifiers

PMID37645257
PMCPMC10461203
OpenAlexW4384436097

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.