Evidence map›Paper›PMID 37645227›Full record

ArticleFrontiers in microbiology2023

Associations between gut microbiota and sleep: a two-sample, bidirectional Mendelian randomization study.

Jun Wu, Baofu Zhang, Shengjie Zhou, Ziyi Huang, Yindong Xu, Xinwu Lu, Xiangtao Zheng, Dong Ouyang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 32 citations in OpenAlex.

  1. Frontiers in nutrition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jun WuDepartment of Vascular Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Baofu ZhangDepartment of Vascular Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Shengjie ZhouDepartment of Obstetrics and Gynecology, Taizhou Women and Children's Hospital of Wenzhou Medical University, Taizhou, Zhejiang, China.
Ziyi HuangDepartment of Vascular Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yindong XuDepartment of Vascular Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xinwu LuDepartment of Vascular Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xiangtao ZhengDepartment of Vascular Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Dong OuyangDepartment of Vascular Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Wenzhou Medical University · CNShanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Previous research has reported that the gut microbiota performs an essential role in sleep through the microbiome-gut-brain axis. However, the causal association between gut microbiota and sleep remains undetermined. Methods: We performed a two-sample, bidirectional Mendelian randomization (MR) analysis using genome-wide association study summary data of gut microbiota and self-reported sleep traits from the MiBioGen consortium and UK Biobank to investigate causal relationships between 119 bacterial genera and seven sleep-associated traits. We calculated effect estimates by using the inverse-variance weighted (as the main method), maximum likelihood, simple model, weighted model, weighted median, and MR-Egger methods, whereas heterogeneity and pleiotropy were detected and measured by the MR pleiotropy residual sum and outlier method, Cochran's Q statistics, and MR-Egger regression. Results: In forward MR analysis, inverse-variance weighted estimates concluded that the genetic forecasts of relative abundance of 42 bacterial genera had causal effects on sleep-associated traits. In the reverse MR analysis, sleep-associated traits had a causal effect on 39 bacterial genera, 13 of which overlapped with the bacterial genera in the forward MR analysis. Discussion: In conclusion, our research indicates that gut microbiota may be involved in the regulation of sleep, and conversely, changes in sleep-associated traits may also alter the abundance of gut microbiota. These findings suggest an underlying reciprocal causal association between gut microbiota and sleep.

Indexed as

causal relationshipgut microbiotainstrumental variableMendelian randomizationsleep

Identifiers

PMID37645227
PMCPMC10461450
OpenAlexW4385837633

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.