Evidence map›Paper›PMID 37644917›Full record

ArticlePNAS nexus2023

Molecular basis for inhibition of methane clathrate growth by a deep subsurface bacterial protein.

Dustin J E Huard, Abigail M Johnson, Zixing Fan, Lydia G Kenney, Manlin Xu, Ran Drori, James C Gumbart, Sheng Dai, Raquel L Lieberman, Jennifer B Glass

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dustin J E HuardSchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332, USA.ORCID https://orcid.org/0000-0003-0891-4360
Abigail M JohnsonSchool of Earth and Atmospheric Sciences, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332, USA.ORCID https://orcid.org/0000-0002-6264-1108
Zixing FanInterdisciplinary Bioengineering Graduate Program, Georgia Institute of Technology, 315 Ferst Dr NW, Atlanta, GA 30332, USA.ORCID https://orcid.org/0000-0001-9157-4613
Lydia G KenneySchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332, USA.ORCID https://orcid.org/0000-0002-2580-2056
Manlin XuSchool of Earth and Atmospheric Sciences, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332, USA.ORCID https://orcid.org/0000-0002-6949-1181
Ran DroriDepartment of Chemistry and Biochemistry, Yeshiva University, 245 Lexington Ave Room 548, New York, NY 10016, USA.ORCID https://orcid.org/0000-0002-6436-5602
James C GumbartSchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332, USA.ORCID https://orcid.org/0000-0002-1510-7842
Sheng DaiSchool of Civil and Environmental Engineering, Georgia Institute of Technology, 790 Atlantic Drive NW, Atlanta, GA 30332, USA.ORCID https://orcid.org/0000-0003-0221-3993
Raquel L LiebermanSchool of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, GA 30332, USA.ORCID https://orcid.org/0000-0001-9345-3735
Jennifer B GlassSchool of Earth and Atmospheric Sciences, Georgia Institute of Technology, 311 Ferst Drive NW, Atlanta, GA 30332, USA.ORCID https://orcid.org/0000-0003-0775-2486
Georgia Institute of Technology · USYeshiva University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methane clathrates on continental margins contain the largest stores of hydrocarbons on Earth, yet the role of biomolecules in clathrate formation and stability remains almost completely unknown. Here, we report new methane clathrate-binding proteins (CbpAs) of bacterial origin discovered in metagenomes from gas clathrate-bearing ocean sediments. CbpAs show similar suppression of methane clathrate growth as the commercial gas clathrate inhibitor polyvinylpyrrolidone and inhibit clathrate growth at lower concentrations than antifreeze proteins (AFPs) previously tested. Unlike AFPs, CbpAs are selective for clathrate over ice. CbpA

Indexed as

methane clathratemolecular simulationsocean sedimentprotein structuresubsurface bacteria

Identifiers

PMID37644917
PMCPMC10462418
OpenAlexW4385800443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.