Evidence map›Paper›PMID 37644881›Full record

ArticleCancer medicine2023

Association of emotional support with quality of life, mental health, and survival in older adults with gastrointestinal malignancies-Results from the CARE registry.

Daniel Clausing, Mackenzie E Fowler, Christian Harmon, Abigail Tucker, Darryl Outlaw, Mehmet Akce, Bassel El-Rayes, Smith Giri, Grant R Williams

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Daniel ClausingDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-2816-2808
Mackenzie E FowlerDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Christian HarmonInstitute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Abigail TuckerInstitute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Darryl OutlawDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0001-9618-6935
Mehmet AkceDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-4747-7722
Bassel El-RayesDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Smith GiriDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-1827-5032
Grant R WilliamsDepartment of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Alabama at Birmingham · US

Funding

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults with Colorectal Cancer: The M&M StudyK08CA234225 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WILLIAMS, GRANT R · 2018 to 2022
$1.0M
AHRQ HHS T32 HS013852NCI NIH HHS K08 CA234225
6 · The paper itself

Abstract

backgroundEmotional support (ES) is the most frequently reported support need among older adults with cancer. Yet, the association of ES with cancer outcomes is largely unknown. This study examined the association of ES with health-related quality of life (HRQoL), mental health, and survival among older adults with gastrointestinal (GI) malignancies.

methodsWe included newly diagnosed older adults (≥60 years) with GI cancer undergoing self-reported geriatric assessment at their first clinic visit. ES was measured using an adaptation of the Medical Outcomes Study (dichotomized adequate ES vs. inadequate ES). Outcomes included physical and mental HRQoL, anxiety, depression, and survival. Multivariable linear regression evaluated the association between ES and HRQoL scores. Multivariable logistic regression evaluated the association of ES with anxiety and depression. All models were adjusted for age at geriatric assessments, race, sex, and cancer type/stage.

results795 participants were included. Median patient age was 68 years (IQR: 64-74), 58% were male, and most cancers were either colorectal (37.9%) or pancreatic (30.8%). Most (77.6%) had adequate ES. Patients with inadequate ES were more likely to be Black (31.5 vs. 20.8%, p = 0.005), disabled (24.1 vs. 10.4%, p < 0.001), widowed/divorced (54.2 vs. 24.8%, p < 0.001) and had lower physical and mental HRQoL t-scores (Physical β: -3.35, 95% CI: -5.25, -1.46; Mental β: -2.46, 95% CI: -4.11, -0.81) and higher odds of depression (aOR: 2.22, CI: 1.34-3.69). This study found no difference between those with adequate ES versus inadequate ES in the proportion of deaths within 1 year of diagnosis (24.3% vs. 24.2%, p = 0.966), or within 2 years of diagnosis (32.4% vs. 33.2%, p = 0.126).

conclusionsOlder adults with inadequate ES have worse physical and mental HRQoL and higher odds of depression compared to those with adequate ES.

Indexed as

Gastrointestinal NeoplasmsQuality of LifeAgedFemaleGeriatric AssessmentHumansMaleMental HealthMiddle AgedRegistriesagingcanceremotional supportgeriatric oncologyhealth-related quality of life

Identifiers

PMID37644881
PMCPMC10557900
OpenAlexW4386271485

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.