Evidence map›Paper›PMID 37644730›Full record

ArticleNeurorehabilitation and neural repair2023

Children With Bilateral Cerebral Palsy Exhibit Bimanual Asymmetric Motor Deficits and EEG Evidence of Dominant Sensorimotor Hemisphere Overreliance During Reaching.

Connor Phillips, Julia Kline, Christopher J Stanley, Thomas C Bulea, Diane L Damiano

Open access · greenAbstract read
In one paragraph

Article in Neurorehabilitation and neural repair, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Connor PhillipsRehabilitation Medicine Department, Neurorehabilitation and Biomechanics Research Section, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Julia KlineRehabilitation Medicine Department, Neurorehabilitation and Biomechanics Research Section, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Christopher J StanleyRehabilitation Medicine Department, Neurorehabilitation and Biomechanics Research Section, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Thomas C BuleaRehabilitation Medicine Department, Neurorehabilitation and Biomechanics Research Section, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Diane L DamianoRehabilitation Medicine Department, Neurorehabilitation and Biomechanics Research Section, Clinical Center, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2770-5356
National Institutes of Health Clinical Center · US

Funding

Near-infrared spectroscopy and electroencephalography to assess and train cortical activation during motor tasksZIACL090081 · CLC · CLINICAL CENTER · PI BULEA, THOMAS · 2022 to 2025
$0k
Intramural NIH HHS ZIA CL090081
6 · The paper itself

Abstract

backgroundReaching is a fundamental motor skill often impaired in cerebral palsy (CP). Studies on manual function, intervention, and underlying brain mechanisms largely focus on unilateral CP. This first electroencephalography (EEG) evaluation of reaching exclusively in bilateral CP aims to quantify and relate brain activation patterns to bimanual deficits in this population.

methodsA total of 15 children with bilateral CP (13.4 ± 2.9 years) and 13 with typical development (TD: 14.3 ± 2.4 years) performed 45 reaches per hand while recording motion capture and EEG data. The Box and Blocks test was administered bilaterally. Cortical sources were identified using independent component analysis and clustered using

resultsThe group with CP demonstrated bimanual motor deficits with slower reaches, lower Box and Blocks scores, and stronger hand preference than in TD. Beta ERD, representing motor execution, was notably higher in the dominant sensorimotor cluster in CP compared to TD. Both groups demonstrated more contralateral than ipsilateral activity in both hands and clusters, with CP showing a less lateralized (more bilateral) alpha response. Higher brain activation was generally related to better function.

conclusionBimanual deficits in bilateral CP and related EEG differences warrant more clinical and research attention particularly earlier in life when greater potential for neural and functional recovery exists.

Indexed as

Cerebral PalsyBrainChildElectroencephalographyHandHumansUpper Extremitybrain imagingbrain injuryevent-related desynchronizationpediatricupper limb

Identifiers

PMID37644730
PMCPMC10529186
OpenAlexW4386272171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.