Evidence map›Paper›PMID 37644211›Full record

ArticleEuropean biophysics journal : EBJ2023

Mammalian Nudt15 hydrolytic and binding activity on methylated guanosine mononucleotides.

Maciej Lukaszewicz, Aleksandra Ferenc-Mrozek, Julia Kokosza, Anna Stefaniuk, Janusz Stepinski, Elzbieta Bojarska, Edward Darzynkiewicz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European biophysics journal : EBJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Maciej LukaszewiczDepartment of Biophysics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093, Warsaw, Poland. Maciej.Lukaszewicz@fuw.edu.pl.ORCID http://orcid.org/0000-0002-2511-7091
Aleksandra Ferenc-MrozekDepartment of Biophysics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093, Warsaw, Poland.
Julia KokoszaDepartment of Biophysics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093, Warsaw, Poland.
Anna StefaniukDepartment of Biophysics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093, Warsaw, Poland.
Janusz StepinskiDepartment of Biophysics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093, Warsaw, Poland.
Elzbieta BojarskaDepartment of Biophysics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093, Warsaw, Poland.
Edward DarzynkiewiczDepartment of Biophysics, Faculty of Physics, University of Warsaw, Pasteura 5, 02-093, Warsaw, Poland.
University of Warsaw · PL

Funding

Narodowe Centrum Nauki UMO-2017/27/B/NZ1/01859
6 · The paper itself

Abstract

The Nudt15 enzyme of the NUDIX protein family is the subject of extensive study due to its action on thiopurine drugs used in the treatment of cancer and inflammatory diseases. In addition to thiopurines, Nudt15 is enzymatically active in vitro on several nucleotide substrates. It has also been suggested that this enzyme may play a role in 5'RNA turnover by hydrolyzing m

Indexed as

GuanosinePyrophosphatasesAnimalsMammalsRNA, MessengerGuanosinePyrophosphatasesRNA, MessengerDifferential scanning fluorimetryEnzyme kineticsMethylated mononucleotidesNUDIX familyNudt15

Identifiers

PMID37644211
PMCPMC10618335
OpenAlexW4386256630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.