ArticleNeuroradiology2023
Association between resistance to cerebrospinal fluid flow and cardiac-induced brain tissue motion for Chiari malformation type I.
Article in Neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- CSF stroke volume measured in pediatric Chiari type 1 Malformation subjects before and after posterior fossa decompression surgery compared with healthy subjects.Fluids and barriers of the CNS · 2026Article
- Patient-specific CFD modeling of CSF flow in Chiari I malformation: denticulate-ligament-induced compartmentalization explains flow patterns.Fluids and barriers of the CNS · 2026Article
- A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs.Fluids and barriers of the CNS · 2025Review
- 3D Quantitative-Amplified Magnetic Resonance Imaging (3D q-aMRI).Bioengineering (Basel, Switzerland) · 2024Article
- Non-invasive biomarkers for spontaneous intracranial hypotension (SIH) through phase-contrast MRI.Journal of neurology · 2024Article
- Safety evaluation of Tofersen in amyotrophic lateral sclerosis based on the FAERS database.Frontiers in neurologyArticle
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Authors and funding
9 authors at 5 institutions in 1 country.
Funding
Abstract
purposeChiari malformation type I (CMI) patients have been independently shown to have both increased resistance to cerebrospinal fluid (CSF) flow in the cervical spinal canal and greater cardiac-induced neural tissue motion compared to healthy controls. The goal of this paper is to determine if a relationship exists between CSF flow resistance and brain tissue motion in CMI subjects.
methodsComputational fluid dynamics (CFD) techniques were employed to compute integrated longitudinal impedance (ILI) as a measure of unsteady resistance to CSF flow in the cervical spinal canal in thirty-two CMI subjects and eighteen healthy controls. Neural tissue motion during the cardiac cycle was assessed using displacement encoding with stimulated echoes (DENSE) magnetic resonance imaging (MRI) technique.
resultsThe results demonstrate a positive correlation between resistance to CSF flow and the maximum displacement of the cerebellum for CMI subjects (r = 0.75, p = 6.77 × 10
conclusionThis study establishes a relationship between CSF flow resistance in the cervical spinal canal and cardiac-induced brain tissue motion in the cerebellum for CMI subjects. Further research is necessary to understand the importance of resistance and brain tissue motion in the symptomatology of CMI.
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