Evidence map›Paper›PMID 37644120›Full record

ReviewCommunications chemistry2023

Combining nitric oxide and calcium sensing for the detection of endothelial dysfunction.

Valeriia D Andreeva, Haley Ehlers, Aswin Krishna R C, Martin Presselt, Lenie J van den Broek, Sylvestre Bonnet

Open access · goldAbstract readReview
In one paragraph

Review in Communications chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Nitric Oxide Signaling and Sensing in Age-Related Diseases.Antioxidants (Basel, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Valeriia D Andreeva *Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-3055-2936
Haley Ehlers *Mimetas B.V., De limes 7, 2342 DH, Oegstgeest, The Netherlands.ORCID http://orcid.org/0009-0008-3312-5148
Aswin Krishna R C *Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
Martin PresseltLeibniz Institute of Photonic Technology (Leibniz-IPHT), Albert-Einstein-Str. 9, 07745, Jena, Germany.
Lenie J van den BroekMimetas B.V., De limes 7, 2342 DH, Oegstgeest, The Netherlands.
Sylvestre BonnetLeiden Institute of Chemistry, Leiden University, Leiden, The Netherlands. bonnet@chem.leidenuniv.nl.ORCID http://orcid.org/0000-0002-5810-3657
Leiden University · NLLeibniz Institute of Photonic Technology · DEMimetas (Netherlands) · NL

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie Skłodowska-Curie Actions (H2020 Excellent Science - Marie Skłodowska-Curie Actions) 813920
6 · The paper itself

Abstract

Cardiovascular diseases are the leading cause of death worldwide and are not typically diagnosed until the disease has manifested. Endothelial dysfunction is an early, reversible precursor in the irreversible development of cardiovascular diseases and is characterized by a decrease in nitric oxide production. We believe that more reliable and reproducible methods are necessary for the detection of endothelial dysfunction. Both nitric oxide and calcium play important roles in the endothelial function. Here we review different types of molecular sensors used in biological settings. Next, we review the current nitric oxide and calcium sensors available. Finally, we review methods for using both sensors for the detection of endothelial dysfunction.

Identifiers

PMID37644120
PMCPMC10465535
OpenAlexW4386241018

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.