ArticleScientific reports2023
Chlorfenapyr metabolism by mosquito P450s associated with pyrethroid resistance identifies potential activation markers.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Chlorfenapyr-pyrethroid nets for pyrethroid-resistant malaria vectors: efficacy, resistance risks, and policy implications.Global health action · 2026Pooled it
- Understanding Chlorfenapyr Toxicity: An Overview of Acute Human Exposure and Clinical Outcomes.Journal of applied toxicology : JAT · 2026Review
- Assessing the Mobility Disruption ofInsects · 2026Article
- Synergistic action of different molecular mechanisms causes striking levels of insecticide resistance in the malaria vectorProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Can dual active ingredient Interceptor® G2 insecticide-treated net (ITN) replace indoor residual spraying (IRS) efficiently? A case study in Sakassou, Côte d'Ivoire.Parasites & vectors · 2026Article
- The Ifakara Ambient Chamber Test (I-ACT) for Evaluation of Indoor Residual Sprays: A Non-Inferiority Test of SylandoInsects · 2026Article
- Construction and validation of a prognostic nomogram for predicting in-hospital mortality of patients with acute chlorfenapyr poisoning.American journal of translational research · 2026Article
- Fitness Trade-Offs and Potential Metabolic Resistance Mechanisms in Geographically Distinct Strains ofInsects · 2025Article
- microRNA Targeting Cytochrome P450 Is Involved in Chlorfenapyr Tolerance in the Silkworm,Insects · 2025Article
- Evaluating the potential of Kalanchoe pinnata, Piper amalago amalago, and other botanicals as economical insecticidal synergists against Anopheles gambiae.Malaria journal · 2025Article
- Rational design and synthesis of new pyrrolone candidates as prospective insecticidal agents against Culex pipiens L. Larvae.Scientific reports · 2024Article
- Substrate promiscuity of key resistance P450s confers clothianidin resistance while increasing chlorfenapyr potency in malaria vectors.Cell reports · 2024Article
- Mosquito Gut Microbiota: A Review.Pathogens (Basel, Switzerland) · 2024Review
- Functional Validation of Endogenous Redox PartnerInternational journal of molecular sciences · 2024Article
- Efficacy of Interceptor G2, Royal Guard and PermaNet 3.0 against pyrethroid-resistant Anopheles gambiae s.l. from Za-Kpota, southern Benin: an experimental hut trial.Parasites & vectors · 2024Article
- The Role ofInsects · 2024Article
- The P450-Monooxygenase Activity and CYP6D1 Expression in the Chlorfenapyr-Resistant Strain ofInsects · 2024Article
- IsCurrent research in parasitology & vector-borne diseases · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Chlorfenapyr is a pro-insecticide increasingly used in combination with pyrethroids such as a-cypermethrin or deltamethrin in insecticide treated bednets (ITNs) to control malaria transmitted by pyrethroid-resistant mosquito populations. Chlorfenapyr requires P450 activation to produce tralopyril and other bioactive metabolites. Pyrethroid resistance is often associated with elevated levels of chemoprotective P450s with broad substrate specificity, which could influence chlorfenapyr activity. Here, we have investigated chlorfenapyr metabolism by a panel of eight P450s commonly associated with pyrethroid resistance in An. gambiae and Ae. aegypti, the major vectors of malaria and arboviruses. Chlorfenapyr was activated to tralopyril by An. gambiae CYP6P3, CYP9J5, CYP9K1 and Ae. aegypti, CYP9J32. The K
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.