Evidence map›Paper›PMID 37644007›Full record

ArticleNature communications2023

γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection.

Juan F Quintana, Matthew C Sinton, Praveena Chandrasegaran, Agatha Nabilla Lestari, Rhiannon Heslop, Bachar Cheaib, John Ogunsola, Dieudonne Mumba Ngoyi, Nono-Raymond Kuispond Swar, Anneli Cooper and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 4 countries.

Juan F Quintana *Wellcome Centre for Integrative Parasitology (WCIP), University of Glasgow, Glasgow, UK. juan.quintana@glasgow.ac.uk.ORCID http://orcid.org/0000-0002-5092-5576
Matthew C Sinton *Wellcome Centre for Integrative Parasitology (WCIP), University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0003-1292-799X
Praveena ChandrasegaranWellcome Centre for Integrative Parasitology (WCIP), University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-7922-6015
Agatha Nabilla LestariWellcome Centre for Integrative Parasitology (WCIP), University of Glasgow, Glasgow, UK.
Rhiannon HeslopWellcome Centre for Integrative Parasitology (WCIP), University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-4332-4393
Bachar CheaibWellcome Centre for Integrative Parasitology (WCIP), University of Glasgow, Glasgow, UK.
John OgunsolaWellcome Centre for Integrative Parasitology (WCIP), University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0001-8319-1225
Dieudonne Mumba NgoyiDepartment of Parasitology, National Institute of Biomedical Research, Kinshasa, Democratic Republic of the Congo.ORCID http://orcid.org/0000-0002-5886-2004
Nono-Raymond Kuispond SwarWellcome Centre for Integrative Parasitology (WCIP), University of Glasgow, Glasgow, UK.
Anneli CooperWellcome Centre for Integrative Parasitology (WCIP), University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0002-1159-142X
Neil A MabbottThe Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-7395-1796
Seth B CoffeltSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0003-2257-2862
Annette MacLeodWellcome Centre for Integrative Parasitology (WCIP), University of Glasgow, Glasgow, UK. annette.macleod@glasgow.ac.uk.ORCID http://orcid.org/0000-0002-0150-5049
Wellcome Centre for Molecular Parasitology · GBCancer Research UK Scotland Institute · GBHeidelberg University · DENational Institute of Biomedical Research · CDRoslin Institute · GBUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

African trypanosomes colonise the skin to ensure parasite transmission. However, how the skin responds to trypanosome infection remains unresolved. Here, we investigate the local immune response of the skin in a murine model of infection using spatial and single cell transcriptomics. We detect expansion of dermal IL-17A-producing Vγ6

Indexed as

DermatitisTrypanosoma brucei bruceiAdiposityAnimalsCachexiaFemaleInflammationInterleukin-17MiceObesityPersistent InfectionInterleukin-17

Identifiers

PMID37644007
PMCPMC10465518
OpenAlexW4386244760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.