Evidence map›Paper›PMID 37643489›Full record

ArticleBiomaterials2023

Succinate in the tumor microenvironment affects tumor growth and modulates tumor associated macrophages.

Sahil Inamdar, Abhirami P Suresh, Joslyn L Mangal, Nathan D Ng, Alison Sundem, Hoda Shokrollahzadeh Behbahani, Thomas E Rubino, Jordan R Yaron, Taravat Khodaei, Matthew Green and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Sahil InamdarChemical Engineering, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, 85281, USA.
Abhirami P SureshBiological Design, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, 85281, USA.
Joslyn L MangalBiological Design, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, 85281, USA.
Nathan D NgMolecular Biosciences and Biotechnology, The College of Liberal Arts and Sciences, Arizona State University, Tempe, AZ, 85281, USA.
Alison SundemChemical Engineering, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, 85281, USA.
Hoda Shokrollahzadeh BehbahaniChemical Engineering, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, 85281, USA.
Thomas E RubinoDepartment of Immunology, Mayo Clinic, Scottsdale, AZ, 85259, USA; Department of Cancer Biology, Mayo Clinic, Scottsdale, AZ, 85259, USA.
Jordan R YaronBiological Design, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, 85281, USA.
Taravat KhodaeiBiomedical Engineering, School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, 85281, USA.
Matthew GreenChemical Engineering, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, 85281, USA; Materials Science and Engineering, School for the Engineering of Matter, Transport, And Energy, Arizona State University, Tempe, AZ, 85281, USA.
Marion CurtisDepartment of Immunology, Mayo Clinic, Scottsdale, AZ, 85259, USA; Department of Cancer Biology, Mayo Clinic, Scottsdale, AZ, 85259, USA; College of Medicine and Science, Mayo Clinic, Scottsdale, AZ, 85259, USA.
Abhinav P AcharyaChemical Engineering, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, 85281, USA; Biological Design, School for the Engineering of Matter, Transport, and Energy, Arizona State University, Tempe, AZ, 85281, USA; Biomedical Engineering, School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, 85281, USA; Materials Science and Engineering, School for the Engineering of Matter, Transport, And Energy, Arizona State University, Tempe, AZ, 85281, USA; Biodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University, Tempe, AZ, 85281, USA; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, United States. Electronic address: abhi.acharya@asu.edu.
Arizona State University · USMayo Clinic in Arizona · US

Funding

Biomaterials-based metabolic rescue of dendritic cells for vaccine designR01AI155907 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ACHARYA, ABHINAV · 2021 to 2025
$1.7M
Local immunometabolism modulating biomaterials for immunosuppressive applicationsR01AR078343 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI ACHARYA, ABHINAV · 2021 to 2025
$1.6M
DMS/NIGMS 1: An Experimental Mathematical Framework for understanding and Controlling Regulatory Delay in Self- Nonself Determination in the Immune System R01GM144966 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI PEET, MATTHEW M · 2021 to 2023
$600k
NIAID NIH HHS R01 AI155907NIAMS NIH HHS R01 AR078343NIGMS NIH HHS R01 GM144966
6 · The paper itself

Abstract

Succinate is an important metabolite that modulates metabolism of immune cells and cancer cells in the tumor microenvironment (TME). Herein, we report that polyethylene succinate (PES) microparticles (MPs) biomaterial mediated controlled delivery of succinate in the TME modulates macrophage responses. Administering PES MPs locally with or without a BRAF inhibitor systemically in an immune-defective aging mice with clinically relevant BRAF

Indexed as

MelanomaSuccinic AcidAnimalsMicePolyethylenesProto-Oncogene Proteins B-rafSuccinatesTumor-Associated MacrophagesTumor MicroenvironmentPolyethylenespoly(ethylene succinate)Proto-Oncogene Proteins B-rafSuccinatesSuccinic AcidCancerImmunometabolismMacrophagesMelanomaSuccinate

Identifiers

PMID37643489
PMCPMC10544711
OpenAlexW4386193113

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.